Document Detail

Investigation of the DCDC2 intron 2 deletion/compound short tandem repeat polymorphism in a large German dyslexia sample.
MedLine Citation:
PMID:  19018237     Owner:  NLM     Status:  MEDLINE    
Dyslexia is a complex disorder manifested by difficulties in learning to read and spell despite conventional instruction, adequate intelligence and sociocultural opportunity. It is among the most common neurodevelopmental disorders with a prevalence of 5-12%. The dyslexia susceptibility locus 2 on chromosome 6p21-p22 is one of the best-replicated linkage regions in dyslexia. On the basis of systematic linkage disequilibrium studies, the doublecortin domain containing protein 2 gene (DCDC2) was identified as a strong candidate gene in this region. Data from a US study have suggested a complex deletion/compound short tandem repeat (STR) polymorphism in intron 2 of DCDC2 as the causative mutation. In this study, we analyzed this polymorphism in 396 German dyslexia trios which included 376 trios previously providing strong support for the DCDC2 locus. We observed no significant deviation from random transmission, neither for the deletion nor for the alleles of the compound STR. We also did not find the deletion or any of the STR alleles to be in linkage disequilibrium with the 2-marker haplotype, which was associated with dyslexia in our sample. We thus conclude that the causative variant/s in DCDC2 conferring susceptibility to dyslexia in our sample remain/s to be identified.
Kerstin U Ludwig; Johannes Schumacher; Gerd Schulte-Körne; Inke R König; Andreas Warnke; Ellen Plume; Heidi Anthoni; Myriam Peyrard-Janvid; Haiying Meng; Andreas Ziegler; Helmut Remschmidt; Juha Kere; Jeffrey R Gruen; Bertram Müller-Myhsok; Markus M Nöthen; Per Hoffmann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychiatric genetics     Volume:  18     ISSN:  1473-5873     ISO Abbreviation:  Psychiatr. Genet.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-21     Completed Date:  2009-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9106748     Medline TA:  Psychiatr Genet     Country:  England    
Other Details:
Languages:  eng     Pagination:  310-2     Citation Subset:  IM    
Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
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MeSH Terms
Chromosomes, Human, Pair 6
Dyslexia / genetics*
Gene Deletion
Linkage Disequilibrium
Microsatellite Repeats*
Microtubule-Associated Proteins / genetics*
Polymorphism, Genetic*
Reg. No./Substance:
0/DCDC2 protein, human; 0/Microtubule-Associated Proteins

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