| Investigation of a Cu(II)-poly(gamma-glutamic acid) complex in aqueous solution and its insulin-mimetic activity. | |
| | |
MedLine Citation:
|
PMID: 17429807 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The complexation between cupric ions (Cu(II)) and poly(gamma-glutamic acid) (gamma-PGA) in aqueous solutions (pH 3-11) has been studied by UV-visible absorption and electron spin resonance (ESR) techniques. Formation of the Cu(II)-gamma-PGA complex is confirmed by the observation of the blue shift of the absorption band in the visible region, anisotropic line shapes in the ESR spectrum at room temperature, and a computer simulation of the visible absorption spectrum of the complex. The structure of the Cu(II)-gamma-PGA complex, depending on the pH, has been determined. The in vitro insulin-mimetic activity of the Cu(II)-gamma-PGA complex is examined by determining both inhibition of free fatty acid release and glucose uptake in isolated rat adipocytes treated with epinephrine, in which the concentration of the Cu(II)-gamma-PGA complex for 50% inhibition of free fatty acid release is very similar to that of CuSO4. However, it is significantly lower than that of a previously reported insulin-mimetic bis(3-hydroxypicolinato)copper(II), [Cu(3hpic)2], complex. |
| | |
Authors:
|
Subarna Karmaker; Tapan K Saha; Hiromu Sakurai |
Related Documents
:
|
3676247 - Involvement of the solid phase of rumen digesta in the interaction between copper, moly... 18964197 - Stability constants and molar absorptivities for complexes of copper(ii) with n-methyld... 17182387 - Treatment of wastewater containing cu(ii)-edta using immobilized tio2/solar light. 11803037 - Roles of metallothionein in copper homeostasis: responses to cu-deficient diets in mice. 19670837 - Architectures of strontium hydroxyapatite microspheres: solvothermal synthesis and lumi... 21202927 - N'-(5-bromo-2-methoxy-benzyl-idene)-3-hydroxy-benzohydrazide methanol hemisolvate. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Macromolecular bioscience Volume: 7 ISSN: 1616-5187 ISO Abbreviation: Macromol Biosci Publication Date: 2007 Apr |
Date Detail:
|
Created Date: 2007-04-17 Completed Date: 2007-10-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101135941 Medline TA: Macromol Biosci Country: Germany |
Other Details:
|
Languages: eng Pagination: 456-66 Citation Subset: IM |
Affiliation:
|
Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adipocytes
/
cytology,
secretion* Animals Biomimetic Materials / chemistry, pharmacology* Cells, Cultured Copper / chemistry, pharmacology* Copper Sulfate / pharmacology Dose-Response Relationship, Drug Fatty Acids / secretion* Hydrogen-Ion Concentration Hypoglycemic Agents / chemistry, pharmacology* Insulin* Male Polyglutamic Acid / analogs & derivatives*, chemistry, pharmacology Rats Spectrophotometry, Ultraviolet |
| Chemical | |
Reg. No./Substance:
|
0/Fatty Acids; 0/Hypoglycemic Agents; 0/poly(gamma-glutamic acid); 11061-68-0/Insulin; 25513-46-6/Polyglutamic Acid; 7440-50-8/Copper; 7758-98-7/Copper Sulfate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Synthesis and characterization of degradable p(HEMA) microgels: use of acid-labile crosslinkers.
Next Document: Efficient modification on PLLA by ozone treatment for biomedical applications.