Document Detail

Investigation of Burkholderia cepacia nosocomial outbreak with high fatality in patients suffering from diseases other than cystic fibrosis.
MedLine Citation:
PMID:  15119360     Owner:  NLM     Status:  MEDLINE    
Over a 1-y period, 26 inpatients at the Jordan University Hospital in Amman were detected with bacteraemia (23 cases) or respiratory tract colonized with B. cepacia (3 cases). A combination of genetic identification and molecular typing has proved that all cases were caused by a single epidemic strain of B. cepacia genomovar IIIa. Nosocomial infections could be documented in 21/26 (81%) patients, mostly with severe underlying or malignant diseases other than cystic fibrosis, but the source of infection was undetected. The overall mortality related to infection with B. cepacia was 42%. All B. cepacia isolates were resistant to ampicillin, amikacin, carbenicillin and gentamicin; and mostly susceptible to piperacillin, chloramphenicol, cotri-moxazole, tetracycline, ceftazidime, and tazocin (62-88%). This study demonstrates the nosocomial and high fatality of B. cepacia genomovar IIIa in Jordanian patients suffering from diseases other than cystic fibrosis.
Asem A Shehabi; Waleed Abu-Al-Soud; Azmi Mahafzah; Najwa Khuri-Bulos; Ilham Abu Khader; Ibn-Sina Ouis; Torkel Wadström
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  36     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2004  
Date Detail:
Created Date:  2004-05-03     Completed Date:  2004-06-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  174-8     Citation Subset:  IM    
Department of Clinical Laboratories, Jordan University Hospital, Amman, Jordan.
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MeSH Terms
Age Distribution
Anti-Bacterial Agents / therapeutic use
Bacteremia / epidemiology*,  microbiology
Burkholderia Infections / diagnosis,  drug therapy,  epidemiology*
Burkholderia cepacia / isolation & purification*
Child, Preschool
Cohort Studies
Cross Infection / drug therapy,  epidemiology*,  microbiology
Cystic Fibrosis / diagnosis,  epidemiology
DNA, Bacterial / analysis
Disease Outbreaks*
Disease Susceptibility
Jordan / epidemiology
Microbial Sensitivity Tests
Middle Aged
Polymerase Chain Reaction / methods
Risk Assessment
Severity of Illness Index
Sex Distribution
Survival Analysis
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/DNA, Bacterial

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