Document Detail

Investigation of the Association between Metabolic Syndrome and Disease Activity in Rheumatoid Arthritis.
MedLine Citation:
PMID:  21666989     Owner:  NLM     Status:  In-Data-Review    
Rheumatoid arthritis (RA) is the most common form of autoimmune arthritis. Increased prevalence of metabolic syndrome (MetS) in RA may occur secondary to specific drug treatment and reduced physical activity associated with this condition. However, some recent studies suggest contradictory theories about the association of RA with MetS. This study was designed to evaluate the frequency of MetS in RA patients and the relationship between MetS with RA disease activity and body mass index (BMI). The study was conducted on 120 RA patients and 431 age- and sex-matched apparently healthy controls. A considerable proportion of patients were being treated with prednisolone and/or methotrexate and/or hydroxychloroquine. Disease activity was measured by the 28 joint count of disease activity score-Cerythrocyte sedimentation rate (DAS28ESR). MetS was evaluated according to International Diabetic Federation (IDF) and Adult Treatment Panel III (ATP III) criteria. The prevalence of MetS was significantly higher in the control group (p = 0.005). We did not find any difference in the prevalence of MetS between the patients with DAS < 3.2 and DAS >= 3.2. There was no association between the DAS28 score and the presence of MetS components by either definition. Multiple logistic regression analysis showed that the odds of a DAS > 3.2 in patients with BMI between 25 and 30 kg/m2 (OR = 0.1, p = 0.01) and BMI > 30 kg/m2 (OR = 0.3, p = 0.1), in comparison to BMI < 25 kg/m2, was 1/5 and 1/3, respectively. RA was not found to increase the risk of MetS. In addition, disease activity in RA patients was not influenced by the presence of MetS.
Maryam Sahebari; Ladan Goshayeshi; Zahra Mirfeizi; Zahra Rezaieyazdi; Mohammad R Hatef; Majid Ghayour-Mobarhan; Saeed Akhlaghi; Amirhossein Sahebkar; Gordon A Ferns
Related Documents :
21802259 - Features of acute dwi abnormalities related to status epilepticus.
24954719 - Myoclonic axial jerks for diagnosing atypical evolution of ataxia telangiectasia.
2455739 - Sonographic investigation of the uterus during artificial uterine cavity distention.
22842299 - Long-term cyclic intravenous iloprost in systemic sclerosis: clinical experience from a...
2120089 - Treatment with pulsatile luteinizing hormone-releasing hormone modulates folliculogenes...
22813439 - Limited ability of the proton-pump inhibitor test to identify patients with gastroesoph...
4096479 - Rupture of the patellar tendon.
6542039 - Radiographic study of acute gastric anisakiasis.
24388549 - Longitudinal hrqol shows divergent trends and identifies constant decliners in asthma a...
Publication Detail:
Type:  Journal Article     Date:  2011-06-09
Journal Detail:
Title:  TheScientificWorldJournal     Volume:  11     ISSN:  1537-744X     ISO Abbreviation:  ScientificWorldJournal     Publication Date:  2011  
Date Detail:
Created Date:  2011-06-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101131163     Medline TA:  ScientificWorldJournal     Country:  England    
Other Details:
Languages:  eng     Pagination:  1195-205     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Bladder cancer and cancer stem cells: basic science and implications for therapy.
Next Document:  Changes in hemodynamics and tissue oxygenation saturation in the brain and skeletal muscle induced b...