| Investigation of Antidiabetic, Antihyperlipidemic, and In Vivo Antioxidant Properties of Sphaeranthus indicus Linn. in Type 1 Diabetic Rats: An Identification of Possible Biomarkers. | |
| | |
MedLine Citation:
|
PMID: 20953435 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
The present investigation was aimed to study the antidiabetic, antihyperlipidemic, and in vivo antioxidant properties of the root of Sphaeranthus indicus Linn. in streptozotocin- (STZ-) induced type 1 diabetic rats. Administration of ethanolic extract of Sphaeranthus indicus root (EESIR) 100 and 200 mg/kg to the STZ-induced diabetic rats showed significant (P < .01) reduction in blood glucose and increase in body weight compared to diabetic control rats. Both the doses of EESIR-treated diabetic rats showed significant (P < .01) alteration in elevated lipid profile levels than diabetic control rats. The EESIR treatment in diabetic rats produced significant increase in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and decrease in thiobarbituric acid reactive substances (TBARS) levels than diabetic control rats. Administration of EESIR 200 mg/kg produced significant (P < .01) higher antioxidant activity than EESIR 100 mg/kg. The high performance liquid chromatography (HPLC) analysis of EESIR revealed the presence of biomarkers gallic acid and quercetin. In conclusion, EESIR possess antidiabetic, antihyperlipidemic, and in vivo antioxidant activity in type 1 diabetic rats. Its antioxidant and lipid lowering effect will help to prevent diabetic complications, and these actions are possibly due to presence of above biomarkers. |
| | |
Authors:
|
S Ramachandran; K Asokkumar; M Uma Maheswari; T K Ravi; A T Sivashanmugam; S Saravanan; A Rajasekaran; J Dharman |
Related Documents
:
|
1706265 - Growth hormone-dependent and -independent regulation of cytochrome p-450 isozyme expres... 2149165 - Regulation of glucose transporter messenger rna levels in rat adipose tissue by insulin. 8864645 - Functional responses of the left and right heart of diabetic rats to alpha- and beta-ad... 12006365 - Mild streptozotocin diabetes in the göttingen minipig. a novel model of moderate insul... 10076185 - Nicotinamide decreases mhc class ii but not mhc class i expression and increases interc... 22852005 - Latent autoimmune diabetes in adults in a population-based cohort of polish patients wi... |
Publication Detail:
|
Type: Journal Article Date: 2010-09-26 |
Journal Detail:
|
Title: Evidence-based complementary and alternative medicine : eCAM Volume: 2011 ISSN: 1741-4288 ISO Abbreviation: Evid Based Complement Alternat Med Publication Date: 2011 |
Date Detail:
|
Created Date: 2010-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101215021 Medline TA: Evid Based Complement Alternat Med Country: England |
Other Details:
|
Languages: eng Pagination: - Citation Subset: - |
Affiliation:
|
Department of Pharmacology, KMCH College of Pharmacy, Tamil Nadu, Coimbatore 641 048, India. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Black tea and theaflavins assist healing of indomethacin-induced gastric ulceration in mice by antio...
Next Document: Ocimum gratissimum Aqueous Extract Protects H9c2 Myocardiac Cells from H(2)O(2)-Induced Cell Apoptos...