| Investigation of [14C] linoleic acid conversion into [14C] arachidonic acid and placental transfer of linoleic and palmitic acids across the perfused human placenta. | |
| | |
MedLine Citation:
|
PMID: 7338607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In five separate experiments in which single placental lobes were perfused, [14C] antipyrine, [3H] dextran and a fatty acid mixture containing [14C] linoleic and [3H] palmitic acids were added to the maternal circuit. Samples of fetal and maternal perfusate, taken at intervals, were analysed for radioactivity and fatty acid content. The relative placental transport rates of antipyrine, linoleic and palmitic acids and the changes in maternal and fetal circuit content of linoleic, palmitic and arachidonic acids were measured. Mean transfer rates of 150, 0.023 and 0.034 mumol min-1 were obtained for [14C] antipyrine, [3H] palmitic and [14C] linoleic acids, respectively. The transfer of [3H] dextran was negligible. The transfer rates of linoleic and palmitic acids did not differ significantly from one another. The maternal circuit content of palmitic and arachidonic acids increased, whereas linoleic acid content decreased. The fetal content of all three acid increased but in the case of arachidonic and palmitic acids the increase was not as great as that seen in the maternal circuit. In no experiment was radioactivity detected in maternal or fetal perfusate arachidonic acid. It is concluded that linoleic and palmitic acids cross the placenta from the maternal to the fetal side. This transfer appears to be non-selective. The large amounts of arachidonic acid that are released into the perfusate probably originate from placental lipids other than free linoleic acid. |
| | |
Authors:
|
C Booth; M C Elphick; W Hendrickse; D Hull |
Related Documents
:
|
9409317 - Prostaglandin f2-like compounds, f2-isoprostanes, are present in increased amounts in h... 15941017 - Role of the conjugated linoleic acid in the prevention of cancer. 19862567 - Thermally induced isomerization of trilinolein and trilinoelaidin at 250 degrees c: ana... 3317407 - Linoleic acid, but not cortisol, stimulates accumulation of casein by mouse mammary epi... 10457177 - Acidic calponin immunoreactivity in postnatal rat brain and cultures: subcellular local... 1855837 - Effect of ascorbic acid on the intragastric environment in patients at increased risk o... |
Publication Detail:
|
Type: In Vitro; Journal Article |
Journal Detail:
|
Title: Journal of developmental physiology Volume: 3 ISSN: 0141-9846 ISO Abbreviation: J. Dev. Physiol. Publication Date: 1981 Jun |
Date Detail:
|
Created Date: 1982-06-14 Completed Date: 1982-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7910737 Medline TA: J Dev Physiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 177-89 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Antipyrine
/
metabolism Arachidonic Acids / metabolism* Biological Transport Carbon Radioisotopes / diagnostic use Female Humans Linoleic Acids / metabolism* Maternal-Fetal Exchange* Oleic Acids / metabolism Palmitic Acids / metabolism* Placenta / metabolism* Pregnancy Stearic Acids / metabolism Tritium / diagnostic use |
| Chemical | |
Reg. No./Substance:
|
0/Arachidonic Acids; 0/Carbon Radioisotopes; 0/Linoleic Acids; 0/Oleic Acids; 0/Palmitic Acids; 0/Stearic Acids; 10028-17-8/Tritium; 60-80-0/Antipyrine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of maternal exercise on fetal and maternal respiration and nutrient metabolism in the pregna...
Next Document: Development of gluconeogenic enzymes in the liver of fasting or suckling newborn pigs.