Document Detail


Investigating structural brain changes of dehydration using voxel-based morphometry.
MedLine Citation:
PMID:  22952926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Dehydration can affect the volume of brain structures, which might imply a confound in volumetric and morphometric studies of normal or diseased brain. Six young, healthy volunteers were repeatedly investigated using three-dimensional T(1)-weighted magnetic resonance imaging during states of normal hydration, hyperhydration, and dehydration to assess volume changes in gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF). The datasets were analyzed using voxel-based morphometry (VBM), a widely used voxel-wise statistical analysis tool, FreeSurfer, a fully automated volumetric segmentation measure, and SIENAr a longitudinal brain-change detection algorithm. A significant decrease of GM and WM volume associated with dehydration was found in various brain regions, most prominently, in temporal and sub-gyral parietal areas, in the left inferior orbito-frontal region, and in the extra-nuclear region. Moreover, we found consistent increases in CSF, that is, an expansion of the ventricular system affecting both lateral ventricles, the third, and the fourth ventricle. Similar degrees of shrinkage in WM volume and increase of the ventricular system have been reported in studies of mild cognitive impairment or Alzheimer's disease during disease progression. Based on these findings, a potential confound in GM and WM or ventricular volume studies due to the subjects' hydration state cannot be excluded and should be appropriately addressed in morphometric studies of the brain.
Authors:
Daniel-Paolo Streitbürger; Harald E Möller; Marc Tittgemeyer; Margret Hund-Georgiadis; Matthias L Schroeter; Karsten Mueller
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Publication Detail:
Type:  Journal Article     Date:  2012-08-29
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-06     Completed Date:  2013-02-07     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e44195     Citation Subset:  IM    
Affiliation:
Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany. paolo@cbs.mpg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Body Weight
Brain / pathology*
Cerebral Ventricles / pathology
Cluster Analysis
Dehydration / cerebrospinal fluid,  pathology*,  urine
Drinking
Female
Humans
Male
Organ Size
Urination
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