| Investigating the stability of neuropsychiatric sub-syndromes with progression of dementia: a 2-year prospective study. | |
| | |
MedLine Citation:
|
PMID: 22250004 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVES: Previous studies have identified sub-syndromes of behavioral and psychological symptoms of dementia. But because of their cross-sectional design, the stability of these sub-syndromes over time remains unknown. METHOD: Behavioral and psychological symptoms of dementia of 84 participants (out of an original sample of 144 patients) with Alzheimer's disease and vascular dementia were assessed by using the Neuropsychiatric Inventory every six months for two years. Principal component factor analysis with Varimax rotation was used to detect neuropsychiatric sub-syndromes at each time point. RESULTS: The 12 symptoms were reduced to four factors at baseline, 12, 18, and 24 months and three factors at six months. None of the factor structures matched the four sub-syndromes previously identified by studies. The most stable group of symptoms were a combination of "psychosis" and "hyperactivity" symptoms (delusions, hallucinations, irritability, agitation), which became stable at 18 months. CONCLUSIONS: The pattern of behavioral and psychological symptoms of dementia sub-syndromes over time has not been studied before, and this research suggests that some stability is evident particularly during the later stages of the disease process. These findings have implications for patients and their caregiver. Copyright © 2012 John Wiley & Sons, Ltd. |
| | |
Authors:
|
Laura Bettney; Shameem Butt; Julie Morris; Amanda Connolly; Charles McCollum; Alistair Burns; Nitin Purandare |
Related Documents
:
|
22001764 - Advances in understanding fragile x syndrome and related disorders. 21607974 - Primary amyloidosis presenting as "dropped head syndrome". 22251534 - Laparoscopic approach for the multiple abdominal vascular entrapment syndrome. 22228094 - The lowe syndrome protein ocrl1 is involved in primary cilia assembly. 21448104 - Metabolic syndrome in patients with depressive disorder - features of comorbidity. 15045864 - Leukoencephalopathy with macrocephaly and mild clinical course. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-16 |
Journal Detail:
|
Title: International journal of geriatric psychiatry Volume: - ISSN: 1099-1166 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8710629 Medline TA: Int J Geriatr Psychiatry Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 John Wiley & Sons, Ltd. |
Affiliation:
|
Manchester Mental Health and Social Care Trust, Park House, North Manchester General Hospital. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Biofuel Feedstock Genomics Resource: a web-based portal and database to enable functional genomi...
Next Document: Using Zebrafish to Unravel the Genetics of Complex Brain Disorders.