| Investigating the role of PDGF as a potential drug therapy in bone formation and fracture healing. | |
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MedLine Citation:
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PMID: 19747084 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Platelet-derived growth factor (PDGF) has been shown in vivo to increase bone formation and supplement fracture healing, and may have a role as a therapeutic agent in the treatment of bone loss and fracture healing in humans. OBJECTIVE: A comprehensive review of the recent literature on the effect of PDGF on bone mineral density and fracture healing. METHODS: In vitro and in vivo evidence was systematically collected using medical search engines MEDLINE/OVID (1950 to March 2008) and EMBASE (1980 to March 2008) databases. RESULTS/CONCLUSION: Evidence to date suggests that PDGF-BB, and to a lesser extent PDGF-AA, may have potential therapeutic use in the treatment of osteoporosis and bone healing in humans. Additionally, by targeting alpha-receptors on osteoblasts, a potential anabolic effect on bone metabolism in humans can be anticipated; however, more research needs to be done to assess the role of beta-receptors in human bone. |
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Authors:
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Simon Graham; Andreas Leonidou; Marie Lester; Manolis Heliotis; Athanasios Mantalaris; Eleftherios Tsiridis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Expert opinion on investigational drugs Volume: 18 ISSN: 1744-7658 ISO Abbreviation: Expert Opin Investig Drugs Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9434197 Medline TA: Expert Opin Investig Drugs Country: England |
Other Details:
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Languages: eng Pagination: 1633-54 Citation Subset: IM |
Affiliation:
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Academic Department of Trauma and Orthopaedics, University of Leeds, School of Medicine, Leeds General Infirmary Teaching Hospitals NHS Trust, Leeds LS1 3EX, UK. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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