| Investigating the post-chemiluminescence behavior of phenothiazine medications in the luminol-potassium ferricyanide system: molecular imprinting-post-chemiluminescence method for the determination of chlorpromazine hydrochloride. | |
| | |
MedLine Citation:
|
PMID: 16547741 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
A new post-chemiluminescence (PCL) phenomenon was observed when phenothiazine medications were injected into the reaction mixture after the chemiluminescence (CL) reaction of luminol and potassium ferricyanide had finished. A possible reaction mechanism was proposed based on studies of the kinetic characteristics of the CL, CL spectra, fluorescence spectra, and on other experiments. The feasibility of determining various phenothiazine medications by utilizing these PCL reactions was examined. A molecular imprinting-post-chemiluminescence (MI-PCL) method was established for the determination of chlorpromazine hydrochloride using a chlorpromazine hydrochloride-imprinted polymer (MIP) as the recognition material. The method displayed high selectivity and high sensitivity. The linear range of the method was 1.0 x 10(-8) approximately 1.0 x 10(-6), with a linear correlation coefficient of 0.9985. The detection limit was 3 x 10(-9) g/ml chlorpromazine hydrochloride, and the relative standard deviation for a 1.0 x 10(-7) g/ml chlorpromazine hydrochloride solution was 4.0% (n = 11). The method has been applied to the determination of chlorpromazine hydrochloride in urine and animal drinking water with satisfactory results. |
| | |
Authors:
|
Weifen Niu; Na Feng; Fei Nie; Jiuru Lu |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-03-18 |
Journal Detail:
|
Title: Analytical and bioanalytical chemistry Volume: 385 ISSN: 1618-2642 ISO Abbreviation: Anal Bioanal Chem Publication Date: 2006 May |
Date Detail:
|
Created Date: 2006-04-21 Completed Date: 2007-06-20 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101134327 Medline TA: Anal Bioanal Chem Country: Germany |
Other Details:
|
Languages: eng Pagination: 153-60 Citation Subset: IM |
Affiliation:
|
School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an, 710062, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antipsychotic Agents / chemistry Chlorpromazine / analysis*, urine Ferricyanides / chemistry* Luminescence* Luminol / chemistry* Phenothiazines / chemistry* Sensitivity and Specificity Water / chemistry |
| Chemical | |
Reg. No./Substance:
|
0/Antipsychotic Agents; 0/Ferricyanides; 0/Phenothiazines; 13746-66-2/potassium ferricyanide; 50-53-3/Chlorpromazine; 521-31-3/Luminol; 7732-18-5/Water |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Rapid determination of reduced and oxidized glutathione levels using a new thiol-masking reagent and...
Next Document: A windowless flow cell-based miniaturized fluorescence detector for capillary flow systems.