Document Detail

Investigating the efficacy of paroxetine in developmental stuttering.
MedLine Citation:
PMID:  19620850     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Paroxetine has been reported to be useful for management of stuttering symptoms, but only a few reports have examined its effects. We have investigated the efficacy of paroxetine in a randomized, placebo-controlled study. METHODS: Five stuttering subjects received paroxetine at 20 mg once daily at night for 12 weeks, and 5 received placebo. The percentages of stuttered words and stuttering-associated movements during speech were measured at baseline and after 6 and 12 weeks of treatment. Moreover, left primary motor cortex excitability was measured using transcranial magnetic stimulation. Specifically, resting and active motor thresholds and the cortical silent period (CSP) were obtained at the same periods in both groups. RESULTS: Paroxetine did not affect the percentage of stuttered words between groups. Stuttering-associated movements, however, during speech in facial muscular districts were significantly reduced in subjects treated with paroxetine. Finally, paroxetine administration shortened the CSP with no effect on motor thresholds. CONCLUSION: Paroxetine may be useful in qualitative management of stuttering symptoms and may act on the stuttering brain by diminution of intracortical inhibition, as revealed by the shortening of the CSP after paroxetine administration.
Pierpaolo Busan; Piero Paolo Battaglini; Massimo Borelli; Pasquale Evaristo; Fabrizio Monti; Giovanna Pelamatti
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Clinical neuropharmacology     Volume:  32     ISSN:  1537-162X     ISO Abbreviation:  Clin Neuropharmacol     Publication Date:    2009 Jul-Aug
Date Detail:
Created Date:  2009-07-31     Completed Date:  2009-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7607910     Medline TA:  Clin Neuropharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  183-8     Citation Subset:  IM    
BRAIN Center of Neuroscience, Department of Life Sciences, University of Trieste, Trieste, Italy.
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MeSH Terms
Facial Muscles / drug effects,  physiopathology
Motor Cortex / drug effects*,  physiopathology
Paroxetine / therapeutic use*
Psychomotor Performance / drug effects
Serotonin Uptake Inhibitors / therapeutic use*
Stuttering / drug therapy*,  physiopathology
Transcranial Magnetic Stimulation / methods
Treatment Outcome
Young Adult
Reg. No./Substance:
0/Serotonin Uptake Inhibitors; 61869-08-7/Paroxetine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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