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Investigating effects of between- and within-host variability on Escherichia coli O157 shedding pattern and transmission.
MedLine Citation:
PMID:  23040120     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Healthy cattle and their environment are the reservoir for the human pathogen Escherichia coli O157. In E. coli O157 epidemiology, supershedders have been loosely defined as cattle that shed high concentrations of E. coli O157 (≥10(4)colony-forming cells (CFU)/g of feces) at a single (or multiple) cross-section in time. Due to the variability in the pathogen shedding level among animals (between-host variability), as well as fluctuations in the level shed by a single animal (within-host variability), it is difficult to interpret fecal bacteria distributions, as well as to parse the relative contribution of between- and within-host variability to the observed shedding patterns at the pen level. We developed an agent-based model that integrates individual animal data on temporal fecal shedding dynamics with pen-level E. coli O157 transmission to study how the temporal (and aggregation) patterns of E. coli O157 shedding loads and prevalence arise at the pen level. We demonstrated that even without between-host variability, the prevalence of animals with concentration of E. coli O157 in feces that exceeds 10(4)CFU/g is similar to that observed in cross-sectional field data. Both within-host and between-host variability can generate supershedders.
Authors:
S Chen; M Sanderson; C Lanzas
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Preventive veterinary medicine     Volume:  -     ISSN:  1873-1716     ISO Abbreviation:  Prev. Vet. Med.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8217463     Medline TA:  Prev Vet Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Affiliation:
Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN, USA. Electronic address: schen25@utk.edu.
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