| Investigating the effect of longitudinal micro-CT imaging on tumour growth in mice. | |
| | |
MedLine Citation:
|
PMID: 21160110 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
The aim of this study is to determine the impact of longitudinal micro-CT imaging on the growth of B16F1 tumours in C57BL/6 mice. Sixty mice received 2 × 10(5) B16F1 cells subcutaneously in the hind flank and were divided into control (no scan), 'low-dose' (80 kVp, 70 mA, 8 s, 0.07 Gy), 'medium-dose' (80 kVp, 50 mA, 30 s, 0.18 Gy) and 'high-dose' (80 kVp, 50 mA, 50 s, 0.30 Gy) groups. All imaging was performed on a fast volumetric micro-CT scanner (GE Locus Ultra, London, Canada). Each mouse was imaged on days 4, 8, 12 and 16. After the final imaging session, each tumour was excised, weighed on an electronic balance, imaged to obtain the final tumour volume and processed for histology. Final tumour volume was used to evaluate the impact of longitudinal micro-CT imaging on the tumour growth. An ANOVA indicated no statistically significant difference in tumour volume (p = 0.331, α = β = 0.1) when discriminating against a treatment-sized effect. Histological samples revealed no observable differences in apoptosis or cell proliferation. We conclude that four imaging sessions, using standard protocols, over the course of 16 days did not cause significant changes in final tumour volume for B16F1 tumours in female C57BL/6 mice (ANOVA, α = β = 0.1, p = 0.331). |
| | |
Authors:
|
W Kyle Foster; Nancy L Ford |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-12-15 |
Journal Detail:
|
Title: Physics in medicine and biology Volume: 56 ISSN: 1361-6560 ISO Abbreviation: Phys Med Biol Publication Date: 2011 Jan |
Date Detail:
|
Created Date: 2011-01-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0401220 Medline TA: Phys Med Biol Country: England |
Other Details:
|
Languages: eng Pagination: 315-26 Citation Subset: IM |
Affiliation:
|
Department of Physics, Ryerson University, Toronto, Ontario M5B 2K3, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Standardized evaluation of simultaneous integrated boost plans on volumetric modulated arc therapy.
Next Document: Intralipid: towards a diffusive reference standard for optical tissue phantoms.