Document Detail


Investigating the benefit of adding a vena cava filter to anticoagulation with fondaparinux sodium in patients with cancer and venous thromboembolism in a prospective randomized clinical trial.
MedLine Citation:
PMID:  22421738     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: The benefit of adding a vena cava filter to anticoagulation in treating cancer patients with venous thromboembolism remains controversial. We initiated this study as the first prospectively randomized trial to evaluate the addition of a vena cava filter placement to anticoagulation with the factor Xa inhibitor fondaparinux sodium in patients with cancer. METHODS: Sixty-four patients with deep vein thrombosis (86 %) and/or pulmonary embolism (55 %) were randomly assigned to receive anticoagulation with fondaparinux sodium with or without a vena cava filter. Endpoints included rates of complications by treatment arm, recurrent thromboembolism, complete resolution of thromboembolism, and survival rates. RESULTS: No patient had a recurrent deep vein thrombosis; two (3 %) patients had new pulmonary emboli, one in each randomized cohort. Major bleeding occurred in three patients (5 %). Two patients on the vena cava filter arm (7 %) had complications from the filter. Median survivals were 493 days in the anticoagulation only arm and 266 days for anticoagulation + vena cava filter (p < 0.57). Complete resolution of venous thromboembolism occurred in 51 % of patients within 8 weeks of initiating anticoagulation. CONCLUSIONS: No advantage was found for placement of a vena cava filter in addition to anticoagulation with fondaparinux sodium in terms of safety, recurrent thrombosis, recurrent pulmonary embolism, or survival in this prospective randomized trial evaluating anticoagulation plus a vena cava filter in cancer patients. Favorable complete resolution rates of thrombosis were observed on both study arms.
Authors:
Myra F Barginear; Richard J Gralla; Thomas P Bradley; Syed S Ali; Iuliana Shapira; Craig Greben; Nanette Nier-Shoulson; Meredith Akerman; Martin Lesser; Daniel R Budman
Related Documents :
20217258 - Clinical significance of cea and ca19-9 in postoperative follow-up of colorectal cancer.
22810808 - Responsiveness of the japanese version of the patient-rated wrist evaluation (prwe-j) a...
22521038 - A real-life study of the use, effectiveness and tolerability of rosiglitazone in france...
20069318 - Is there a benefit to operating on patients (bedridden or in wheelchairs) with advanced...
12081738 - Permanent sacral nerve stimulation for treatment of idiopathic constipation.
24601188 - Impact of ethanol, dry care and human milk on the time for umbilical cord separation.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-16
Journal Detail:
Title:  Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer     Volume:  -     ISSN:  1433-7339     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9302957     Medline TA:  Support Care Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Hofstra North Shore-LIJ School of Medicine, Monter Cancer Center, Lake Success, NY, USA, MBarginear@nshs.edu.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Cardiac remodeling is not modulated by overexpression of muscle LIM protein (MLP).
Next Document:  Effects of a Rhodiola rosea L. extract on the acquisition, expression, extinction, and reinstatement...