Document Detail


Investigating the efficacy of subharmonic aided pressure estimation for portal vein pressures and portal hypertension monitoring.
MedLine Citation:
PMID:  22920550     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The efficacy of using subharmonic emissions from Sonazoid microbubbles (GE Healthcare, Oslo, Norway) to track portal vein pressures and pressure changes was investigated in 14 canines using either slow- or high-flow models of portal hypertension (PH). A modified Logiq 9 scanner (GE Healthcare, Milwaukee, WI, USA) operating in subharmonic mode (f(transmit): 2.5 MHz, f(receive): 1.25 MHz) was used to collect radiofrequency data at 10-40% incident acoustic power levels with 2-4 transmit cycles (in triplicate) before and after inducing PH. A pressure catheter (Millar Instruments, Inc., Houston, TX, USA) provided reference portal vein pressures. At optimum insonification, subharmonic signal amplitude changes correlated with portal vein pressure changes; r ranged from -0.82 to -0.94 and from -0.70 to -0.73 for PH models considered separately or together, respectively. The subharmonic signal amplitudes correlated with absolute portal vein pressures (r: -0.71 to -0.79). Statistically significant differences between subharmonic amplitudes, before and after inducing PH, were noted (p ≤ 0.01). Portal vein pressures estimated using subharmonic aided pressure estimation did not reveal significant differences (p > 0.05) with respect to the pressures obtained using the Millar pressure catheter. Subharmonic-aided pressure estimation may be useful clinically for portal vein pressure monitoring.
Authors:
Jaydev K Dave; Valgerdur G Halldorsdottir; John R Eisenbrey; Daniel A Merton; Ji-Bin Liu; Jian-Hua Zhou; Hsin-Kai Wang; Suhyun Park; Scott Dianis; Carl L Chalek; Feng Lin; Kai E Thomenius; Daniel B Brown; Flemming Forsberg
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2012-08-21
Journal Detail:
Title:  Ultrasound in medicine & biology     Volume:  38     ISSN:  1879-291X     ISO Abbreviation:  Ultrasound Med Biol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-10     Completed Date:  2013-02-06     Revised Date:  2014-01-17    
Medline Journal Info:
Nlm Unique ID:  0410553     Medline TA:  Ultrasound Med Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1784-98     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arterial Pressure
Blood Pressure Determination / methods*
Contrast Media
Dogs
Ferric Compounds / diagnostic use*
Hypertension, Portal / physiopathology*,  ultrasonography*
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods
Iron / diagnostic use*
Oxides / diagnostic use*
Portal Vein / physiopathology*,  ultrasonography*
Reproducibility of Results
Sensitivity and Specificity
Ultrasonography / methods*
Grant Support
ID/Acronym/Agency:
R21 HL081892/HL/NHLBI NIH HHS; R21 HL081892/HL/NHLBI NIH HHS; RC1 DK087365/DK/NIDDK NIH HHS; RC1 DK087365/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Contrast Media; 0/Ferric Compounds; 0/Oxides; 0/Sonazoid; E1UOL152H7/Iron
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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