| Investigating the efficacy of subharmonic aided pressure estimation for portal vein pressures and portal hypertension monitoring. | |
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MedLine Citation:
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PMID: 22920550 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of using subharmonic emissions from Sonazoid microbubbles (GE Healthcare, Oslo, Norway) to track portal vein pressures and pressure changes was investigated in 14 canines using either slow- or high-flow models of portal hypertension (PH). A modified Logiq 9 scanner (GE Healthcare, Milwaukee, WI, USA) operating in subharmonic mode (f(transmit): 2.5 MHz, f(receive): 1.25 MHz) was used to collect radiofrequency data at 10-40% incident acoustic power levels with 2-4 transmit cycles (in triplicate) before and after inducing PH. A pressure catheter (Millar Instruments, Inc., Houston, TX, USA) provided reference portal vein pressures. At optimum insonification, subharmonic signal amplitude changes correlated with portal vein pressure changes; r ranged from -0.82 to -0.94 and from -0.70 to -0.73 for PH models considered separately or together, respectively. The subharmonic signal amplitudes correlated with absolute portal vein pressures (r: -0.71 to -0.79). Statistically significant differences between subharmonic amplitudes, before and after inducing PH, were noted (p ≤ 0.01). Portal vein pressures estimated using subharmonic aided pressure estimation did not reveal significant differences (p > 0.05) with respect to the pressures obtained using the Millar pressure catheter. Subharmonic-aided pressure estimation may be useful clinically for portal vein pressure monitoring. |
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Authors:
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Jaydev K Dave; Valgerdur G Halldorsdottir; John R Eisenbrey; Daniel A Merton; Ji-Bin Liu; Jian-Hua Zhou; Hsin-Kai Wang; Suhyun Park; Scott Dianis; Carl L Chalek; Feng Lin; Kai E Thomenius; Daniel B Brown; Flemming Forsberg |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2012-08-21 |
Journal Detail:
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Title: Ultrasound in medicine & biology Volume: 38 ISSN: 1879-291X ISO Abbreviation: Ultrasound Med Biol Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-09-10 Completed Date: 2013-02-06 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0410553 Medline TA: Ultrasound Med Biol Country: England |
Other Details:
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Languages: eng Pagination: 1784-98 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Radiology, Thomas Jefferson University, Philadelphia, PA 19107, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Pressure Blood Pressure Determination / methods* Contrast Media Dogs Ferric Compounds / diagnostic use* Hypertension, Portal / physiopathology*, ultrasonography* Image Enhancement / methods Image Interpretation, Computer-Assisted / methods Iron / diagnostic use* Oxides / diagnostic use* Portal Vein / physiopathology*, ultrasonography* Reproducibility of Results Sensitivity and Specificity Ultrasonography / methods* |
| Grant Support | |
ID/Acronym/Agency:
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R21 HL081892/HL/NHLBI NIH HHS; RC1 DK087365/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Ferric Compounds; 0/Oxides; 0/Sonazoid; 7439-89-6/Iron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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