Document Detail


Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance.
MedLine Citation:
PMID:  23134263     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We challenged the performance of our previous heroin vaccine with a similar vaccine containing a more hydrolytically stable hapten analogue and a Th1 adjuvant (CpG ODN). Our results indicate that the elements of our previous vaccine are essential for its anti-heroin potency, i.e., a chemically labile hapten and an exclusively Th2 humoral response elicited by alum. Such design elements are critical for producing next-generation heroin vaccines.
Authors:
Paul T Bremer; Kim D Janda
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-11-15
Journal Detail:
Title:  Journal of medicinal chemistry     Volume:  55     ISSN:  1520-4804     ISO Abbreviation:  J. Med. Chem.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-13     Completed Date:  2013-02-26     Revised Date:  2013-12-18    
Medline Journal Info:
Nlm Unique ID:  9716531     Medline TA:  J Med Chem     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10776-80     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / metabolism*
Antibody Formation / immunology
Haptens / metabolism*
Heroin / immunology*
Humans
Hydrolysis
Th1 Cells / immunology*
Vaccines / immunology*
Grant Support
ID/Acronym/Agency:
R01 DA026625/DA/NIDA NIH HHS; R01-DA026625/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/Haptens; 0/Vaccines; 70D95007SX/Heroin
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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