| Investigating the effects of a hydrolytically stable hapten and a Th1 adjuvant on heroin vaccine performance. | |
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MedLine Citation:
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PMID: 23134263 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We challenged the performance of our previous heroin vaccine with a similar vaccine containing a more hydrolytically stable hapten analogue and a Th1 adjuvant (CpG ODN). Our results indicate that the elements of our previous vaccine are essential for its anti-heroin potency, i.e., a chemically labile hapten and an exclusively Th2 humoral response elicited by alum. Such design elements are critical for producing next-generation heroin vaccines. |
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Authors:
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Paul T Bremer; Kim D Janda |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2012-11-15 |
Journal Detail:
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Title: Journal of medicinal chemistry Volume: 55 ISSN: 1520-4804 ISO Abbreviation: J. Med. Chem. Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-13 Completed Date: 2013-02-26 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 9716531 Medline TA: J Med Chem Country: United States |
Other Details:
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Languages: eng Pagination: 10776-80 Citation Subset: IM |
Affiliation:
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Department of Chemistry, The Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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metabolism* Antibody Formation / immunology Haptens / metabolism* Heroin / immunology* Humans Hydrolysis Th1 Cells / immunology* Vaccines / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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R01 DA026625/DA/NIDA NIH HHS; R01-DA026625/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Haptens; 0/Vaccines; 561-27-3/Heroin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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