Document Detail

Inverted skin changes induced by estrogen and estrogen/glucocorticoid on aging dermis.
MedLine Citation:
PMID:  8701786     Owner:  NLM     Status:  MEDLINE    
To evaluate hormone replacement therapy effects at the peripheral level, the present trial explored the oral effects of mestranol (80 micrograms/day for 10 days) and mestranol plus paramethasone (80 micrograms + 6 mg/day for 10 days) on the skin of postmenopausal women. This double-blind study included 13 patients. Skin biopsies were obtained from the thigh area by a single punch, 5 mm in diameter, before and after treatment, and the sections, six per sample, were micrometrically evaluated. Various features of the epidermis and dermis layers were stained using the hematoxylin and eosin, Masson, Verhoeff's and Gomori techniques. Statistically significant changes were found in the papillar dermis thickness; mestranol reduced it and mestranol plus paramethasone increased it. The current results encourage widening these observations of the possible advantage of this estrogen/glucocorticoid combination, in order to alleviate the cellular degenerative process.
V Cortés-Gallegos; G L Villanueva; I Sojo-Aranda; F J Santa Cruz
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  10     ISSN:  0951-3590     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-09-05     Completed Date:  1996-09-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  125-8     Citation Subset:  IM    
Gonadal Disease Center, Medical Research Unit, Social Security Mexican Institute, México City.
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MeSH Terms
Administration, Oral
Aging / drug effects,  pathology
Anti-Inflammatory Agents / pharmacology,  therapeutic use*
Double-Blind Method
Estradiol Congeners / pharmacology,  therapeutic use*
Estrogen Replacement Therapy*
Mestranol / pharmacology,  therapeutic use*
Middle Aged
Paramethasone / pharmacology,  therapeutic use*
Skin / drug effects*,  pathology
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Estradiol Congeners; 53-33-8/Paramethasone; 72-33-3/Mestranol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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