Document Detail

Invertebrate models of age-related muscle degeneration.
MedLine Citation:
PMID:  19563864     Owner:  NLM     Status:  MEDLINE    
Functional and structural deterioration of muscles is an inevitable consequence of ageing in a wide variety of animal species. What underlies these changes is a complex network of interactions between the muscle-intrinsic and muscle-extrinsic factors, making it very difficult to distinguish between the cause and the consequence. Many of the genes, structures, and processes implicated in mammalian skeletal muscle ageing are preserved in invertebrate species Drosophila melanogaster and Caenorhabditis elegans. The absence in these organisms of mechanisms that promote muscle regeneration, and substantially different hormonal environment, warrant caution when extrapolating experimental data from studies conducted in invertebrates to mammalian species. The simplicity and accessibility of these models, however, offer ample opportunities for studying age-related myopathologies as well as investigating drugs and therapies to alleviate them.
Hrvoje Augustin; Linda Partridge
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-06-27
Journal Detail:
Title:  Biochimica et biophysica acta     Volume:  1790     ISSN:  0006-3002     ISO Abbreviation:  Biochim. Biophys. Acta     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-09-14     Completed Date:  2010-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0217513     Medline TA:  Biochim Biophys Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1084-94     Citation Subset:  IM    
Institute of Healthy Ageing and GEE, University College London, London WC1E 6BT, UK.
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MeSH Terms
Aging / genetics,  physiology*
Caenorhabditis elegans / genetics,  physiology*
DNA, Mitochondrial / genetics
Disease Models, Animal
Drosophila melanogaster / genetics,  physiology*
Muscle, Skeletal / metabolism,  physiopathology*
Muscular Atrophy / genetics,  physiopathology
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/DNA, Mitochondrial

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