Document Detail

Inverse temporal changes of lipoxin A4 and leukotrienes in children with Henoch-Schönlein purpura.
MedLine Citation:
PMID:  19264468     Owner:  NLM     Status:  MEDLINE    
The pathogenesis of Henoch-Schönlein purpura (HSP) is not clearly understood. It remains unclear how changes of lipoxin A(4) (LXA(4)) that acts as a "braking signal" in inflammatory process occur in patients with HSP. In this study, we determined the temporal changes of blood and urinary LXA(4), Leukotriene (LT)B(4) and urinary LTE(4) in 49 children with HSP. Inverse temporal changes between gradually increased blood and urinary LXA(4) and gradually decreased blood and urinary LTB(4) and urinary LTE(4) were found in patients with HSP. Furthermore, both 15-S-hydroxyeicosatetraenoic acid and LXA(4) inhibited the LTB(4)-induced chemotaxis of leukocytes and release of LTB(4) from leukocytes obtained from the patients in the active phase of HSP. In 22 children with HSP nephritis, concordant with the gradually increased severity of mesangial proliferation and proteinuria, the glomerular expressions of 15-lipoxygenase and the levels of urinary LXA(4) gradually decreased and the glomerular expressions of LTC(4) synthase and the urinary LTE(4) and LTB(4) gradually increased. The levels of blood and urinary LXA(4) in patients with HSP nephritis were lower than those in patients with purpura alone in early resolution of HSP. The levels of blood and urinary LTB(4) and urinary LTE(4) in the patients with HSP nephritis were higher than those in patients with purpura alone in early resolution of HSP. There was positive correlation between blood LTB(4) and serum C-reactive protein in 49 children with HSP. These data suggest that LTs may play a proinflammatory and profibrotic role in the pathogenesis of HSP, and insufficiency of LXA(4) may be responsible for the patients with HSP whose illness become more serious.
Sheng-Hua Wu; Pei-Yuan Liao; Pei-Ling Yin; Yong-Mei Zhang; Ling Dong
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-03-04
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  80     ISSN:  1532-2823     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-05-18     Completed Date:  2009-08-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, People's Republic of China.
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MeSH Terms
C-Reactive Protein / metabolism
Leukocytes / metabolism
Leukotriene B4 / blood,  metabolism*,  urine
Leukotriene E4 / blood,  metabolism*,  urine*
Lipoxins / blood,  metabolism*,  urine
Purpura, Schoenlein-Henoch / metabolism*,  pathology
Reg. No./Substance:
0/Lipoxins; 0/lipoxin A4; 71160-24-2/Leukotriene B4; 75715-89-8/Leukotriene E4; 9007-41-4/C-Reactive Protein

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