Document Detail

Inverse shift in serum polyunsaturated and monounsaturated fatty acids is associated with adverse dilatation of the heart.
MedLine Citation:
PMID:  19723686     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cardiac dilatation is associated with impaired pump function, progression of heart failure and electrical instability. Risk of sudden death is associated with a low blood level of n-3 polyunsaturated fatty acids. OBJECTIVE: The hypothesis was, therefore, addressed that left ventricular dilatation as assessed by echocardiography is associated with a reduced serum polyunsaturated fatty acid level. METHODS: Fatty acids were determined with gas chromatography/mass spectrometry in serum of 308 patients with dilative heart failure unrelated to myocardial infarction (age 48 (SD12) years, NYHA class 2.2 (0.6), ejection fraction 31% (10%)). RESULTS: The extent of left ventricular dilatation as assessed by left ventricular end-diastolic diameter was associated with a reduction of both n-3 and n-6 polyunsaturated fatty acids. The n-3 docosahexaenoic acid (1.0% (0.5%) vs 1.3% (0.6%), p<0.001) and the n-6 arachidonic acid (4.6% (1.8%) vs 5.2% (1.9%), p<0.01) were reduced in patients with left ventricular dilatation (end-diastolic diameter, 68-90 mm, upper tertile vs 48-61 mm, lower tertile). By contrast, monounsaturated fatty acids were increased (the n-9 oleic acid 26.1% (4.8%) vs 23.9% (4.8%), p<0.01). A low docosahexaenoic acid (0.01-0.9%, lower tertile vs 1.4-3.1%, upper tertile) was associated with greater left ventricular dilatation (end-diastolic diameter, 67 (8) vs 63 (7) mm, p<0.001). The cut-off for the absence of severe dilatation (end-diastolic diameter >70 mm) was set at >1.24% docosahexaenoic acid. In our sample, the negative-predictive value for severe dilatation was 91% and sensitivity was 84%. CONCLUSIONS: Docosahexaenoic acid provides a new sensitive biomarker for monitoring and detecting severe left ventricular dilatation in heart failure patients.
H Rupp; T P Rupp; P Alter; B Maisch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-08-31
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  96     ISSN:  1468-201X     ISO Abbreviation:  Heart     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-01     Completed Date:  2010-06-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  England    
Other Details:
Languages:  eng     Pagination:  595-8     Citation Subset:  AIM; IM    
Philipps University, Department of Internal Medicine-Cardiology, Experimental Cardiology Laboratory, Karl-von-Frisch-Strasse 1, Marburg, Germany.
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MeSH Terms
Biological Markers / blood
Cardiomyopathy, Dilated / blood,  etiology*
Docosahexaenoic Acids / blood
False Positive Reactions
Fatty Acids, Monounsaturated / blood*
Fatty Acids, Unsaturated / blood*
Middle Aged
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Monounsaturated; 0/Fatty Acids, Unsaturated; 25167-62-8/Docosahexaenoic Acids

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