| Inverse relationship of serum adiponectin concentration with type 2 diabetes mellitus incidence in middle-aged Japanese workers: 6-year follow-up. | |
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MedLine Citation:
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PMID: 22228701 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: It was suggested that inflammation may mediate or modify biological effects of adiponectin. Few studies examined the association between circulating adiponectin levels and type 2 diabetes (T2DM) while controlling for variables related to inflammation. In addition, East Asians were reported to have lower adiponectin levels but higher diabetes prevalence at a given degree of obesity than Caucasians, raising some possibility that adiponectin-diabetes association may differ by race. Therefore, we prospectively investigated the associations with a number of covariates including C-reactive protein and smoking status in a cohort of Japanese workers aged 35-66 years. METHODS: Serum adiponectin concentration and other covariates were obtained in 2002 for 3,008 civil servants free of T2DM at baseline in urban/suburban Japan. T2DM incidence was defined as the year when annually-assessed fasting blood glucose level first exceeded 126 mg/dl, or self-reported initiation of medication through 2007. T2DM incidence was examined in relation to the adiponectin quintile. RESULTS: Age- and sex-adjusted homeostasis model assessment insulin resistance (HOMA-IR) was inversely associated with adiponectin quintiles at baseline. During six years of follow-up, 164 individuals developed T2DM. In a fully-adjusted model, hazard ratios (95% confidence intervals) of T2DM in Q2 to Q5 compared to Q1 were 0.62 (0.41-0.94), 0.44 (0.25-0.77), 0.40 (0.20-0.78) and 0.85 (0.48-1.49), respectively. CONCLUSIONS: Low adiponectin was related to increased incidence of T2DM independent of baseline levels of blood glucose, insulin and CRP as well as other confounding variables in middle-aged Japanese. Whether high adiponectin is linearly associated with decreased T2DM risk needs further investigation. Copyright © 2012 John Wiley & Sons, Ltd. |
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Authors:
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Yuanying Li; Hiroshi Yatsuya; Hiroyasu Iso; Hideaki Toyoshima; Koji Tamakoshi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-6 |
Journal Detail:
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Title: Diabetes/metabolism research and reviews Volume: - ISSN: 1520-7560 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883450 Medline TA: Diabetes Metab Res Rev Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 John Wiley & Sons, Ltd. |
Affiliation:
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Public Health, Department of Social and Environmental Medicine, Osaka University Graduate School of Medicine, Osaka, Japan; Department of Public Health and Health Systems, Nagoya University Graduate School of Medicine, Nagoya, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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