Document Detail


Inverse relationship between adult hippocampal cell proliferation and synaptic rewiring in the dentate gyrus.
MedLine Citation:
PMID:  18481284     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Adult neurogenesis is a key feature of the hippocampal dentate gyrus (DG). Neurogenesis is accompanied by synaptogenesis as new cells become integrated into the circuitry of the hippocampus. However, little is known to what extent the embedding of new neurons rewires the pre-existing network. Here we investigate synaptic rewiring in the DG of gerbils (Meriones unguiculatus) under different rates of adult cell proliferation caused by different rearing conditions as well as juvenile methamphetamine treatment. Surprisingly, we found that an increased cell proliferation reduced the amount of synaptic rewiring. To help explain this unexpected finding, we developed a novel model of dentate network formation incorporating neurogenesis and activity-dependent synapse formation and remodelling. In the model, we show that homeostasis of neuronal activity can account for the inverse relationship between cell proliferation and synaptic rewiring.
Authors:
Markus Butz; Gertraud Teuchert-Noodt; Keren Grafen; Arjen van Ooyen
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Hippocampus     Volume:  18     ISSN:  1098-1063     ISO Abbreviation:  Hippocampus     Publication Date:  2008  
Date Detail:
Created Date:  2008-08-28     Completed Date:  2009-01-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108167     Medline TA:  Hippocampus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  879-98     Citation Subset:  IM    
Copyright Information:
(c) 2008 Wiley-Liss, Inc.
Affiliation:
Bernstein Center for Computational Neuroscience Göttingen, Max-Planck-Institut for Dynamics and Selforganization, Bunsenstr. 10, Göttingen, Germany. mbutz@bccn-goettingen.de
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Proliferation*
Dentate Gyrus / cytology,  physiology*
Gerbillinae
Hippocampus / cytology,  physiology*
Male
Nerve Net / cytology,  physiology
Neural Networks (Computer)*
Neuronal Plasticity / physiology*
Synapses / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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