Document Detail


Inverse correlation between testosterone and ventricle ejection fraction, hemodynamics and exercise capacity in heart failure patients with erectile dysfunction.
MedLine Citation:
PMID:  18601760     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Neurohormonal activation and abnormalities in growth hormone and testosterone concentrations have been reported in heart failure (HF). Erectile dysfunction(ED) is common in these patients and contributes to a low quality of life. No data are known regarding the correlation between testosterone and hemodynamics, exercise capacity and cardiac function in HF patients with ED, a marker of endothelial dysfunction. The aim of this study was to correlate testosterone levels with cardiac function, hemodynamic and exercise capacity in HF patients with ED. MATERIALS AND METHODS: Fifteen HF patients underwent a six-minute treadmill cardiopulmonary walking test (6'CWT) and, ten minutes later, a maximum cardiopulmonary exercise test. Also, testosterone and other hormones were determined at rest. RESULTS: Among hemodynamic variables only diastolic blood pressure on 6'CWT was correlated with testosterone levels(r=-0.66, p=0.007). The variables on exercise tests, VE/VCO2 slope and oxygen consumption did not show any correlation, except the distance at 6'CWT (r=0.50, p=0,047). Right and left ventricle ejection fraction showed inverse correlation with testosterone (r=-0.55, p=0.03 and r=-0.69, p=0.004 respectively). CONCLUSION: Testosterone levels correlated directly with distance at six-minute cardiopulmonary walk test and inversely with diastolic blood pressure, right and left ventricle ejection fraction in heart failure patients with erectile dysfunction. Further elucidation of mechanisms as regards testosterone action in these patients is warranted.
Authors:
Edimar A Bocchi; Vitor O Carvalho; Guilherme V Guimaraes
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International braz j urol : official journal of the Brazilian Society of Urology     Volume:  34     ISSN:  1677-5538     ISO Abbreviation:  Int Braz J Urol     Publication Date:    2008 May-Jun
Date Detail:
Created Date:  2008-07-08     Completed Date:  2009-09-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101158091     Medline TA:  Int Braz J Urol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  302-10; discussion 310-2     Citation Subset:  IM    
Affiliation:
Laboratory of Heart Failure and Transplantation, Heart Institute, Incor, University of Sao Paulo, SP, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Blood Pressure / physiology*
Erectile Dysfunction / blood,  etiology,  physiopathology*
Exercise Test
Exercise Tolerance / physiology
Health Status
Heart Failure / blood,  complications,  physiopathology*
Humans
Male
Middle Aged
Statistics, Nonparametric
Stroke Volume / physiology
Testosterone / blood*
Time Factors
Ventricular Dysfunction, Left / physiopathology*
Chemical
Reg. No./Substance:
58-22-0/Testosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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