| Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology. | |
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MedLine Citation:
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PMID: 1985406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Essential antioxidants were determined in plasma of middle-aged men representing 16 European study populations, which differed sixfold in age-specific mortality from ischemic heart disease (IHD). In 12 populations with "common" plasma cholesterol (5.7-6.2 mmol/L) and blood pressure, both classical risk factors lacked significant correlations to IHD mortality, whereas absolute levels of vitamin E (alpha-tocopherol) showed a strong inverse correlation (r2 = 0.63, P = 0.002). Evaluating all populations, cholesterol and diastolic blood pressure were moderately associated, but their correlation was inferior to that of vitamin E. In stepwise regression and multiple regression analysis, mortality was predictable to 62% by lipid-standardized vitamin E, to 79% by vitamin E and cholesterol, to 83% after inclusion of lipid-standardized vitamin A (retinol), and to 87% by all the above parameters plus blood pressure. Thus, in the present study the cross-cultural differences of IDH mortality are primarily attributable to plasma status of vitamin E, which might have protective functions. |
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Authors:
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K F Gey; P Puska; P Jordan; U K Moser |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 53 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1991 Jan |
Date Detail:
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Created Date: 1991-02-01 Completed Date: 1991-02-01 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 326S-334S Citation Subset: AIM; IM |
Affiliation:
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Institute of Biochemistry and Molecular Biology, University of Berne, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Cholesterol / blood Cohort Studies Coronary Disease / mortality* Cross-Cultural Comparison Cross-Sectional Studies Europe / epidemiology Humans Male Middle Aged Multivariate Analysis Regression Analysis Risk Factors Vitamin E / blood* |
| Chemical | |
Reg. No./Substance:
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1406-18-4/Vitamin E; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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