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Inverse association of estimated cystatin C- and creatinine-based glomerular filtration rate with left ventricular mass: Results from the Study of Health in Pomerania.
MedLine Citation:
PMID:  22884092     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Left ventricular hypertrophy (LVH) is an independent predictor of cardiovascular disease in the general population and in patients with chronic kidney disease. The objective of this study was to investigate the association of estimated glomerular filtration rate (eGFR) with left ventricular mass index (LVMI), LVH and left ventricular geometry. A question of clinical relevance is whether estimated glomerular filtration rate based on cystatin C (eGFR(cystatinC)) is a better marker for cardiovascular risk than estimated glomerular filtration rate based on creatinine (eGFR(creatinine)). METHODS: The study sample included 2830 individuals from the population-based Study of Health in Pomerania (SHIP). LVH was defined as echocardiographic LVMI >48g/m(2.7) in men and >44g/m(2.7) in women. Kidney function, as assessed by eGFR, was determined from established equations: the creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation and a cystatin-based multivariable equation. RESULTS: We found an inverse association between eGFR and LVMI. This association was stronger in models with eGFR(cystatinC) than in models with eGFR(creatinine). Subjects with moderately-to-severely decreased kidney function (defined as eGFR 15-<60mL/min per 1.73m(2)) had higher odds for abnormal geometric patterns of the left ventricle than subjects with normal eGFR when eGFR(cystatinC) was used. CONCLUSIONS: The findings suggest that eGFR(cystatinC) is superior to eGFR(creatinine) for assessing the risk of cardiovascular disease.
Authors:
Nicole Aumann; Sebastian E Baumeister; André Werner; Henri Wallaschofski; Anke Hannemann; Matthias Nauck; Rainer Rettig; Stephan B Felix; Marcus Dörr; Henry Völzke; Wolfgang Lieb; Sylvia Stracke
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-8
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
Institute for Community Medicine, Ernst-Moritz-Arndt-University Greifswald, Walther-Rathenau-Str. 48, 17487 Greifswald, Germany.
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