Document Detail

Inverse association between prostatic polyunsaturated fatty acid and risk of locally advanced prostate carcinoma.
MedLine Citation:
PMID:  15495177     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: An effect of fatty acids has been implicated in men with advanced-stage prostate carcinoma and in men who have died of the disease. To evaluate the influence of fatty acids in men with prostate carcinoma at earlier stages, the authors examined the relation between prostatic concentrations of fatty acids and locally advanced prostate carcinoma in men with clinically organ-confined disease. METHODS: Fatty acids were measured by capillary gas chromatography in fresh, nonmalignant prostate tissue specimens collected during surgery from 196 men undergoing radical prostatectomy for localized prostate carcinoma. Two-sided, two-sample Student t tests compared mean concentrations in men with extraprostatic disease (pT3-4N0-1M0) with control men with organ-confined disease. Logistic regression accounted for clinical stage, prostate-specific antigen level, Gleason sum, and other factors. RESULTS: Percent total prostatic polyunsaturated fatty acid (PUFA) was found to be inversely associated with risk of locally advanced prostate carcinoma (n=52) (odds ratio [OR]=0.93, 95% confidence interval [95% CI], 0.87-0.99; P=0.035). Risk of seminal vesicle involvement accounted for this association (OR=0.86, 95% CI, 0.78-0.95; P=0.003). Percent omega-3 fatty acid (eicosapentanoic + docosahexanoic acids) and percent arachidonic acid also were found to be inversely related to the risk of seminal vesicle involvement (OR=0.52, 95% CI, 0.30-0.90; P=0.02; and OR=0.84, 95% CI,; 0.75-0.95; P=0.005, respectively). CONCLUSIONS: Prostatic PUFA levels appear to influence the risk of locally advanced prostate carcinoma in men with clinically organ-confined disease. This association may be mediated through the immune system.
Vincent L Freeman; Mohsen Meydani; Kwan Hur; Robert C Flanigan
Related Documents :
939957 - Fertilization acid of sea urchin eggs is not a consequence of cortical granule exocytosis.
7065637 - Determination of acid phosphatase activity in normal human lymphocytes.
7202387 - Citrate synthesis from fatty acids and amino acids in rat ventral prostate.
6166747 - Antiandrogenic effect of delta-9-tetrahydrocannabinol in adult castrated rats.
3096377 - Mucus glycoprotein secretion by duodenal mucosa in response to luminal arachidonic acid.
8829367 - Membrane permeation and intracellular trafficking of long chain fatty acids: insights f...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  101     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2004-12-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2744-54     Citation Subset:  AIM; IM    
Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois 60612-4336, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arachidonic Acid / metabolism
Fatty Acids, Omega-3 / metabolism
Fatty Acids, Unsaturated / metabolism*
Linoleic Acid / metabolism
Middle Aged
Prostatic Neoplasms / metabolism*
Reg. No./Substance:
0/Fatty Acids, Omega-3; 0/Fatty Acids, Unsaturated; 2197-37-7/Linoleic Acid; 506-32-1/Arachidonic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  "Hour-glass" shape of the uterus in the diagnosis and treatment of cervical pregnancy.
Next Document:  Maxillary and sphenoid sinus aplasia in Turkish individuals: a retrospective review using computed t...