| The inverse benefit law: how drug marketing undermines patient safety and public health. | |
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MedLine Citation:
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PMID: 21233426 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Recent highly publicized withdrawals of drugs from the market because of safety concerns raise the question of whether these events are random failures or part of a recurring pattern. The inverse benefit law, inspired by Hart's inverse care law, states that the ratio of benefits to harms among patients taking new drugs tends to vary inversely with how extensively the drugs are marketed. The law is manifested through 6 basic marketing strategies: reducing thresholds for diagnosing disease, relying on surrogate endpoints, exaggerating safety claims, exaggerating efficacy claims, creating new diseases, and encouraging unapproved uses. The inverse benefit law highlights the need for comparative effectiveness research and other reforms to improve evidence-based prescribing. |
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Authors:
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Howard Brody; Donald W Light |
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Publication Detail:
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Type: Journal Article Date: 2011-01-13 |
Journal Detail:
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Title: American journal of public health Volume: 101 ISSN: 1541-0048 ISO Abbreviation: Am J Public Health Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-10 Completed Date: 2011-03-29 Revised Date: 2013-04-15 |
Medline Journal Info:
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Nlm Unique ID: 1254074 Medline TA: Am J Public Health Country: United States |
Other Details:
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Languages: eng Pagination: 399-404 Citation Subset: AIM; IM |
Affiliation:
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Institute for the Medical Humanities, Department of Family Medicine, University of Texas Medical Branch, Galveston, TX 77555-1311, USA. habrody@utmb.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adverse Drug Reaction Reporting Systems Drug Industry / ethics* Drug and Narcotic Control / organization & administration* Health Policy* Humans Marketing / ethics* Prescription Drugs / adverse effects* Product Surveillance, Postmarketing Public Health* Safety* |
| Chemical | |
Reg. No./Substance:
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0/Prescription Drugs |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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