Document Detail

Inverse association between circulating levels of soluble receptor for advanced glycation end-products and coronary plaque burden.
MedLine Citation:
PMID:  22785051     Owner:  NLM     Status:  MEDLINE    
AIM: Low levels of soluble receptor for advanced glycation end-products (sRAGE) have been reported to be associated with coronary artery disease (CAD) and peripheral atherosclerosis. This study explored the relationship between circulating levels of sRAGE and the characteristics of coronary vessels detected by 64-slice computed tomography angiography (CTA).
METHODS: In this cross-sectional study we included 127 consecutive patients with CAD but without acute coronary syndrome. Quantitative volumetric analysis of the lumen and plaque burden of the vessel wall (soft and calcific components) was performed for the three major coronary vessels. Each component was expressed as a percentage of vessel volume and utilized in per-patient analysis. The patients were classified into two groups according to the presence of calcium volume: non-calcified plaque (NCP) group (calcium volume %=0) and calcified plaque (CP) group (calcium volume % >0).
RESULTS: In the NCP group, but not in the CP group, simple regression analysis revealed a negative association of total plaque burden % with sRAGE (β=-0.378, p=0.0019) and HDL cholesterol (β=-0.368, p=0.003) and a positive association with creatinine (β=0.258, p=0.041) and male gender (β=0.317, p=0.01). After adjusting for confounding factors, the total plaque burden % remained significantly associated only with sRAGE (β=-0.358, p=0.011).
CONCLUSIONS: Circulating sRAGE levels are associated in an inverse manner with non-calcified plaque burden, suggesting that it may be related with early atherosclerosis and plaque progression.
Giuseppina Basta; Serena Del Turco; Teresa Navarra; Alessandro Mazzarisi; Franca Cocci; Michele Coceani; Massimiliano Bianchi; Mathis Schlueter; Paolo Marraccini
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-07-06
Journal Detail:
Title:  Journal of atherosclerosis and thrombosis     Volume:  19     ISSN:  1880-3873     ISO Abbreviation:  J. Atheroscler. Thromb.     Publication Date:  2012  
Date Detail:
Created Date:  2012-11-02     Completed Date:  2013-04-12     Revised Date:  2013-07-16    
Medline Journal Info:
Nlm Unique ID:  9506298     Medline TA:  J Atheroscler Thromb     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  941-8     Citation Subset:  IM    
CNR Institute of Clinical Physiology, Pisa, Italy.
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MeSH Terms
Atherosclerosis / blood,  pathology
Coronary Artery Disease / blood*,  pathology
Coronary Vessels / pathology
Cross-Sectional Studies
Disease Progression
Middle Aged
Multidetector Computed Tomography
Plaque, Atherosclerotic / blood*,  pathology
Receptors, Immunologic / blood*
Risk Factors
Vascular Calcification / pathology
Reg. No./Substance:
0/Receptors, Immunologic; 0/advanced glycosylation end-product receptor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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