Document Detail

Inverse Association between Cancer Risks and Age in Schizophrenia Patients: a 12-year Nationwide Cohort Study.
MedLine Citation:
PMID:  23281874     Owner:  NLM     Status:  Publisher    
The association between schizophrenia and cancer risks is controversial in the clinical and epidemiological literature. Studies from different populations, tumor sites, or health care systems have provided inconsistent findings. In the present study, we examine a less well-investigated hypothesis that age plays a crucial role in cancer risks in schizophrenia. We conduct a nationwide cohort study using Taiwan's National Health Insurance Research Database (NHIRD) between 1995 and 2007. Overall, gender-, and age-stratified standardized incidence ratios (SIR) were used to investigate the pattern of cancer risks by age. Among the 102,202 schizophrenia patients, 1,738 developed cancers after diagnosis of schizophrenia (SIR=0.92, 95% CI: 0.90-0.96). However, the age-stratified SIRs declined with age (for example, age 20-29, SIR=1.97, 95% CI: 1.85-2.33; age 60-69, SIR=0.68, 95% CI: 0.65-0.78; age≥70, SIR=0.36, 95% CI: 0.34-0.45) in both genders and for major cancers. Cancer risks in schizophrenia patients were lower in the cancers that are more likely to develop at older age in the general population, such as stomach cancer (SIR=0.62, 95% CI: 0.57-0.80), pancreas cancer (SIR=0.49, 95% CI: 0.39-0.84) and prostate cancer (SIR=0.35, 95% CI: 0.29-0.58). By contrast, cancer risks were higher in the cancers that have a younger onset age, such as cancers of nasopharynx (SIR=1.18, 95% CI: 1.08-1.49), breast (SIR=1.50, 95% CI: 1.44-1.66) and uterine corpus (SIR=2.15, 95% CI: 1.98-2.74). Schizophrenia populations' unique age structures and early aging potential might contribute to the observed inverse relationship between age and cancer risks. Higher cancer comorbidity in young schizophrenia patients deserves more attention.
Chun-Yuan Lin; Hsien-Yuan Lane; Tsi-Ting Chen; Yu-Hsin Wu; Chun-Ying Wu; Vivian Y Wu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-3
Journal Detail:
Title:  Cancer science     Volume:  -     ISSN:  1349-7006     ISO Abbreviation:  Cancer Sci.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101168776     Medline TA:  Cancer Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Japanese Cancer Association.
Institute of Clinical Medical Science, Medical College, China Medical University, Taichung, Taiwan; Department of Psychiatry, Changhua Hospital, Changhua, Taiwan; National Changhua University of Education, Changhua, Taiwan.
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