Document Detail

Invasive squamous cell carcinoma of the skin: defining a high-risk group.
MedLine Citation:
PMID:  16788750     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Unlike its more common non-invasive form, invasive squamous cell carcinoma (SCC) of the skin can be biologically aggressive and is prone to recur. The objectives of this study were to identify relevant clinicopathologic prognostic factors associated with the outcomes of patients with invasive SCC in order to define a high-risk group. METHODS: We retrospectively reviewed the records of patients with invasive cutaneous SCC of the trunk or extremities who received surgical treatment at a tertiary care cancer center over the past 10 years. We examined the patterns of presentation, all known clinical and histological risk factors for recurrence, and their association with survival. RESULTS: 136 patients were identified, of whom 102 (74%) were male. Patterns of presentation included primary (n = 91), locally recurrent (n = 16), regional nodal (n = 24), and distant (n = 5) disease. Univariate analysis identified poorly differentiated carcinomas (hazard ratio [HR] = 2.92, P = .016), scar carcinomas (HR = 3.12, P = .008), tumor size > 2 cm (HR = 3.79, P = .006), and regional nodal disease (HR = 5.77, P < .0001) as significant risk factors for recurrence or death. On multivariate analysis, however, only regional nodal disease at presentation (HR = 7.64, P < .0001) was found to be significant. CONCLUSIONS: Patients with invasive SCCs metastatic to regional nodes constitute a group at high risk for recurrence and death. Such patients should be considered for adjuvant therapy trials.
John T Mullen; Lei Feng; Yan Xing; Paul F Mansfield; Jeffrey E Gershenwald; Jeffrey E Lee; Merrick I Ross; Janice N Cormier
Publication Detail:
Type:  Journal Article     Date:  2006-05-22
Journal Detail:
Title:  Annals of surgical oncology     Volume:  13     ISSN:  1068-9265     ISO Abbreviation:  Ann. Surg. Oncol.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-21     Completed Date:  2006-11-07     Revised Date:  2007-07-18    
Medline Journal Info:
Nlm Unique ID:  9420840     Medline TA:  Ann Surg Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  902-9     Citation Subset:  IM    
Department of Surgical Oncology, Unit 444, The University of Texas M. D. Anderson Cancer Center, 1400 Holcombe Boulevard, Houston, Texas, 77030, USA.
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MeSH Terms
Aged, 80 and over
Carcinoma, Squamous Cell / secondary*,  surgery
Follow-Up Studies
Lymph Nodes / pathology*
Lymphatic Metastasis
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local / pathology*
Neoplasm Staging
Retrospective Studies
Risk Factors
Skin Neoplasms / pathology*,  surgery
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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