Document Detail

Invasive pulmonary aspergillosis in nonimmunocompromised, nonneutropenic hosts.
MedLine Citation:
PMID:  3726394     Owner:  NLM     Status:  MEDLINE    
Invasive pulmonary aspergillosis occurs predominantly in individuals who are neutropenic or who have severe defects in cell-mediated immunity. The isolation of Aspergillus from respiratory secretions of normal hosts usually signifies tracheobronchial colonization, not disease. Recent experience with three nonimmunocompromised patients who had invasive pulmonary aspergillosis, each of whom had Aspergillus isolated from respiratory secretions early in his illness, led to a reassessment of the significance of the isolation of Aspergillus from tracheobronchial secretions. Two of 10 nonimmunocompromised, nonleukopenic individuals who had pulmonary infiltrates and whose sputum yielded Aspergillus had invasive pulmonary aspergillosis, whereas two of five individuals who had pulmonary infiltrates and whose bronchial washings grew Aspergillus had invasive disease. These findings indicate that invasive pulmonary aspergillosis should be considered when Aspergillus is isolated from the respiratory secretions of anyone who has pneumonia, regardless of host defense status.
G H Karam; F M Griffin
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Reviews of infectious diseases     Volume:  8     ISSN:  0162-0886     ISO Abbreviation:  Rev. Infect. Dis.     Publication Date:    1986 May-Jun
Date Detail:
Created Date:  1986-08-21     Completed Date:  1986-08-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905878     Medline TA:  Rev Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  357-63     Citation Subset:  IM    
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MeSH Terms
Aspergillosis / blood,  diagnosis*,  immunology
Leukocyte Count
Lung Diseases, Fungal / blood,  diagnosis*,  immunology
Middle Aged
Sputum / microbiology

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