| Invasive prenatal diagnostic techniques. | |
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MedLine Citation:
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PMID: 16533654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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As aneuploid screening evolves to the first trimester a complimentary diagnostic procedure becomes increasingly important. Chorionic villus (CVS) sampling has emerged as the only safe invasive prenatal diagnostic procedure prior to the 14(th) week of gestation. Over 2 decades of experience have demonstrated the accuracy, efficacy and safety of CVS. The karyotype is identical to that of the fetus in over 98% of cases. In the remaining 1 to 2% confined placental mosaicism (CPM) occurs. Current knowledge of the etiology of CPM allows accurate clinical interpretation, the recognition of cases of fetal uniparental disomy, and identification of pregnancies at risk for poor perinatal outcome. Prospective comparative studies have demonstrated that with equally experienced operators, CVS and second trimester amniocentesis have similar procedure induced miscarriage rates. When CVS procedures are performed after 10 weeks gestation, no increased risk of fetal anomalies has been demonstrated. |
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Authors:
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Ronald J Wapner |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Seminars in perinatology Volume: 29 ISSN: 0146-0005 ISO Abbreviation: Semin. Perinatol. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2006-03-14 Completed Date: 2006-08-18 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7801132 Medline TA: Semin Perinatol Country: United States |
Other Details:
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Languages: eng Pagination: 401-4 Citation Subset: IM |
Affiliation:
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Division of Maternal Fetal Medicine, Columbia University Medical Center, New York, NY 10032, USA. rw2191@columbia.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aneuploidy Chorionic Villi Sampling / adverse effects Congenital Abnormalities / epidemiology, etiology Female Gestational Age* Humans Karyotyping Mosaicism Placenta Pregnancy Pregnancy Outcome Pregnancy Trimester, First Prenatal Diagnosis / adverse effects*, methods* Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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