Document Detail


Invasive pneumococcal disease in the population of Victoria.
MedLine Citation:
PMID:  11062804     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To estimate morbidity and mortality rates for invasive Streptococcus pneumoniae (pneumococcal) disease in the non-Indigenous population of Victoria. DESIGN AND SETTING: Survey using data from a statewide voluntary laboratory surveillance scheme (1989-1998), statewide hospital discharge database (1995-1998), medical records of notified patients (1994-1995) and serotyping of notified isolates (1994-1998). MAIN OUTCOME MEASURES: Incidence of pneumococcal bacteraemia and pneumonia; predisposing factors; serotypes of isolates. RESULTS: Minimum estimates of annual incidence of invasive disease, based on laboratory surveillance data for 1995-1998, were 59 per 100,000 for children aged < 2 years, 25 per 100,000 for people aged > or = 65 years, and 8 per 100,000 overall. Annual incidence of pneumococcal pneumonia, calculated from hospital discharge data, was 99 per 100,000 for those aged > or = 65 years. Manifestations of invasive pneumococcal disease varied with age, with meningitis more common in infants, and pneumonia most common in older patients. A predisposing factor for pneumococcal infection was present in 48% of patients. Most isolates from infants (83%) belonged to serotypes in the proposed seven-valent infant vaccine, and 91% of isolates from people aged > or = 2 years belonged to serotypes in the current 23-valent adult vaccine. CONCLUSIONS: S. pneumoniae continues to be a major cause of morbidity and mortality in young children and the elderly in Victoria. More widespread use of the currently available pneumococcal vaccine in adults and introduction of an effective vaccine for infants should greatly reduce incidence of the disease.
Authors:
G G Hogg; J E Strachan; R A Lester
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Medical journal of Australia     Volume:  173 Suppl     ISSN:  0025-729X     ISO Abbreviation:  Med. J. Aust.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-21     Completed Date:  2000-11-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400714     Medline TA:  Med J Aust     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  S32-5     Citation Subset:  IM    
Affiliation:
Microbiological Diagnostic Unit, University of Melbourne, VIC. g.hogg@mdu.unimelb.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Distribution
Aged
Bacteremia / epidemiology
Child
Child, Preschool
Humans
Incidence
Infant
Middle Aged
Pneumococcal Infections / epidemiology*,  mortality,  prevention & control
Pneumococcal Vaccines
Population Surveillance / methods*
Risk Factors
Serotyping
Streptococcus pneumoniae / classification,  pathogenicity
Victoria / epidemiology
Chemical
Reg. No./Substance:
0/Pneumococcal Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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