Document Detail

Invasive neonatal candidiasis: an overview.
MedLine Citation:
PMID:  14626498     Owner:  NLM     Status:  MEDLINE    
Until the 1980s, recovery of Candida species from normally sterile body sites in high-risk infants was often dismissed as contamination. Such delay in diagnosis often resulted in death, multifocal disease, or significant morbidity, outcomes that still occur today. Problems establishing the diagnosis of invasive candidiasis persist, while the frequency of this infection in increasingly fragile and smaller premature infants appears to be increasing. Standard culture techniques have limited sensitivity and often take several days for recovery of Candida when positive. Heightened suspicion and improved diagnostic tools are needed. Less toxic antifungal agents with better tissue penetration profiles will help. Better understanding of risk factors and pathogenesis may permit more effective strategies for prophylaxis and appropriately targeted empiric antifungal therapy.
Rachel L Chapman; Roger G Faix
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in perinatology     Volume:  27     ISSN:  0146-0005     ISO Abbreviation:  Semin. Perinatol.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-11-19     Completed Date:  2004-03-04     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7801132     Medline TA:  Semin Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  352-6     Citation Subset:  IM    
Division of Neonatal-Perinatal Medicine, Yale University School of Medicine, New Haven, CT 06520-8064, USA.
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MeSH Terms
Candida / classification,  isolation & purification
Candidiasis / diagnosis*,  drug therapy*
Cross Infection / diagnosis*,  drug therapy*
Fungemia / diagnosis*,  drug therapy*
Infant, Newborn
Intensive Care Units, Neonatal

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