Document Detail

Invasive mold sinusitis: 17 cases in immunocompromised patients and review of the literature.
MedLine Citation:
PMID:  9195079     Owner:  NLM     Status:  MEDLINE    
A 10-year retrospective analysis of invasive mold infections in hospitalized patients was performed to characterize the epidemiology and clinical features of invasive fungal sinusitis. Seventeen cases of invasive mold sinusitis were identified. Eleven cases were caused by Aspergillus flavus, three were caused by unspecified species, and one each was caused by Aspergillus fumigatus, Rhizopus species, and Alternaria species, respectively. Fifteen patients had hematologic malignancies, and two had end-stage liver disease. The most common presenting symptom was periorbital swelling (seven patients). Sinusitis was diagnosed a median of 19 days after admission. Eight patients (47%) survived; six of these patients were treated with both amphotericin B and surgery. Postmortem examination of six patients showed evidence of disseminated disease; the brain was the most common extrapulmonary site (four patients). To our knowledge, this is the largest currently reported series on invasive mold sinusitis; our report extends the information on invasive mold sinusitis and shows that aggressive therapeutic and surgical interventions are needed to prevent rapid progression of disease in immunocompromised patients.
P C Iwen; M E Rupp; S H Hinrichs
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  24     ISSN:  1058-4838     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  1997 Jun 
Date Detail:
Created Date:  1997-07-31     Completed Date:  1997-07-31     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1178-84     Citation Subset:  IM    
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-6495, USA.
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MeSH Terms
Immunocompromised Host
Middle Aged
Mycoses / diagnosis,  etiology*,  therapy
Retrospective Studies
Sinusitis / diagnosis,  etiology*,  therapy

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