Document Detail

Invasive mechanical ventilation in exacerbations of chronic obstructive pulmonary disease.
MedLine Citation:
PMID:  9785822     Owner:  NLM     Status:  MEDLINE    
Exacerbations of chronic obstructive pulmonary disease are appropriately treated when severe airflow obstruction does not respond to intensive therapy, including, at times, noninvasive mechanical ventilation. Ventilatory strategies include avoidance of the ventilatory complications of dynamic pulmonary hyperinflation with its resultant intrinsic positive end-expiratory pressure, thereby decreasing the risk of hypotension and barotrauma. Initial ventilator settings should include an expiratory flow rate between 8-10 L.min-1, a tidal volume of 8-10 and a respiratory rate of 11-14 breaths.min-1 as well as an inspiratory flow rate of 100 L.min-1. Further adjustments are made on the basis of gas exchange and pulmonary mechanics. Medical therapies include beta-agonists and corticosteroids.
S K Pingleton
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo     Volume:  53     ISSN:  1122-0643     ISO Abbreviation:  Monaldi Arch Chest Dis     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-11-13     Completed Date:  1998-11-13     Revised Date:  2008-06-02    
Medline Journal Info:
Nlm Unique ID:  9307314     Medline TA:  Monaldi Arch Chest Dis     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  337-42     Citation Subset:  IM    
Division of Pulmonary and Critical Care Medicine, University of Kansas Medical Center, Kansas City 66160, USA.
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MeSH Terms
Anti-Inflammatory Agents / therapeutic use
Bronchodilator Agents / therapeutic use
Hypnotics and Sedatives / therapeutic use
Lung Diseases, Obstructive / complications,  therapy*
Respiration, Artificial*
Respiratory Insufficiency / etiology,  therapy*
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Bronchodilator Agents; 0/Hypnotics and Sedatives; 0/Steroids

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