Document Detail

Invasive infections due to Trichoderma species: report of 2 cases, findings of in vitro susceptibility testing, and review of the literature.
MedLine Citation:
PMID:  12439799     Owner:  NLM     Status:  MEDLINE    
Trichoderma species are filamentous fungi that were previously considered to be culture contaminants. We report 2 well-documented cases of invasive Trichoderma infections, and we comprehensively review the literature on this topic. Trichoderma species are mainly responsible for continuous ambulatory peritoneal dialysis-associated peritonitis (7 cases) and invasive infections in immunocompromised patients (9 cases) with a hematologic malignancy or solid-organ transplant. Definitive diagnosis is difficult to achieve because of the lack of specific diagnosis tools. Species identification can benefit from a molecular approach. Trichoderma longibrachiatum is the most common species involved in these infections. Regardless of the type of infection, the prognosis was poor, with 8 deaths among 18 cases. This may be partially because of the resistance of these organisms to the majority of available antifungal agents, including amphotericin B. Trichoderma species now should be added to the growing list of emerging filamentous fungal pathogens.
T Chouaki; V Lavarde; L Lachaud; C P Raccurt; C Hennequin
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2002-11-07
Journal Detail:
Title:  Clinical infectious diseases : an official publication of the Infectious Diseases Society of America     Volume:  35     ISSN:  1537-6591     ISO Abbreviation:  Clin. Infect. Dis.     Publication Date:  2002 Dec 
Date Detail:
Created Date:  2002-11-19     Completed Date:  2002-11-27     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9203213     Medline TA:  Clin Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1360-7     Citation Subset:  IM    
Service de Parasitologie-Mycologie, Centre Hospitalier Universitaire Amiens, Amiens, France.
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MeSH Terms
Aged, 80 and over
Antifungal Agents / pharmacology*
Drug Resistance, Microbial / physiology*
Microbial Sensitivity Tests
Middle Aged
Mycoses / microbiology*,  mortality
Trichoderma / drug effects*
Reg. No./Substance:
0/Antifungal Agents

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