Document Detail


Invasive imaging techniques for the assessment of vulnerable plaque.
MedLine Citation:
PMID:  17019397     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Coronary artery disease is the leading cause of mortality and morbidity in the Western world and an ever-increasing problem in developing countries. Unheralded acute coronary syndromes (ACS) are common initial manifestations of coronary atherosclerosis and are often caused by lesions which have previously not generated symptoms. Histopathological studies have identified several plaque morphologies associated with ACS. However, the natural history of these high-risk or vulnerable lesions remains unknown and the limited knowledge about their eventual prognosis is provided by retrospective histopathological studies. Detection of these vulnerable plaques in vivo is essential to study their natural history and to evaluate potential treatment modalities and, therefore, may ultimately have an important impact on the prevention of acute myocardial infarction and death. Currently, there are several diagnostic imaging tools capable of evaluating determinants of plaque vulnerability. These techniques can provide information on the vessel lumen and wall size, tissue composition and the status of inflammation. This article aims to review the current status of these imaging techniques.
Authors:
N Kukreja; H M Garcia-Garcia; P W Serruys
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Minerva cardioangiologica     Volume:  54     ISSN:  0026-4725     ISO Abbreviation:  Minerva Cardioangiol     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-10-04     Completed Date:  2007-03-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0400725     Medline TA:  Minerva Cardioangiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  603-17     Citation Subset:  IM    
Affiliation:
Thoraxcenter, Erasmus Medical Center, Dr. Molewaterplein 40, 3015 GD Rotterdam, the Netherlands.
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MeSH Terms
Descriptor/Qualifier:
Coronary Artery Disease / diagnosis*
Humans
Magnetic Resonance Imaging
Tomography, Optical Coherence
Ultrasonography, Interventional

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