| Invasive fungal infections in congenital immunodeficiencies. | |
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MedLine Citation:
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PMID: 20545959 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Abstract Both acquired and congenital immunodeficiencies may be associated with increased susceptibility to invasive fungal infections (IFIs), depending on the type of immune deficit. IFIs occur with increased frequency in patients with phagocytic and cellular immune defects but are rarely observed in those with humoral or complement deficits. Among congenital immune disorders, chronic granulomatous disease and hyper-IgE syndrome are most frequently associated with IFIs; variable susceptibility to fungal pathogens also exhibit patients with severe combined immunodeficiency, X-linked hyper-IgM syndrome, Wiskott-Aldrich syndrome, DiGeorge syndrome, common variable immunodeficiency, defects in the interferon-gamma/interleukin-12 axis and myeloperoxidase deficiency. Aspergillus, Candida, Cryptococcus, Histoplasma and other fungal genera are variably implicated in causing invasive infections in these patients. Prompt diagnosis of IFIs in this patient population requires a high degree of suspicion together with a knowledge of their clinical presentation and limitations of diagnostic modalities. Apart from administration of appropriate antifungal agents, successful management often requires the addition of surgical intervention. Adjunctive immunotherapy may be considered, although not systematically studied. Prophylactic interferon-gamma and itraconazole administration have been shown to reduce the risk of IFIs in patients with chronic granulomatous disease; however, the possibility of infections with azole-resistant organisms following long-term itraconazole prophylaxis should not be overlooked. |
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Authors:
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Charalampos Antachopoulos |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-6-08 |
Journal Detail:
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Title: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases Volume: - ISSN: 1469-0691 ISO Abbreviation: - Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-6-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9516420 Medline TA: Clin Microbiol Infect Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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3 Department of Pediatrics, Aristotle University, Hippokration Hospital, Thessaloniki, Greece. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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