Document Detail


Invasive esophageal aspergillosis associated with acute myelogenous leukemia: successful therapy with combination caspofungin and liposomal amphotericin B.
MedLine Citation:
PMID:  17130115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aspergillosis is one of the most common invasive fungal infections in patients with leukemia. In this patient group, this form of Aspergillus infection is a life-threatening condition with a mortality of 50-100%. The lungs are most often affected, but the esophagus can also be involved.The authors report the case of a child with leukemia who developed invasive esophageal aspergillosis. The condition was diagnosed by microscopic examination of endoscopic biopsy specimens. The patient was already receiving empirical liposomal amphotericin B when the diagnosis was made, so a second antifungal (caspofungin) was added to the regimen. This combination was successful. This case to demonstrates a case of successful treatment of invasive esophageal aspergillosis using combination therapy of liposomal amphotericin B and caspofungin.
Authors:
Bulent Alioglu; Zekai Avci; Oguz Canan; Figen Ozcay; Beyhan Demirhan; Namik Ozbek
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pediatric hematology and oncology     Volume:  24     ISSN:  1521-0669     ISO Abbreviation:  Pediatr Hematol Oncol     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2006-11-28     Completed Date:  2006-12-19     Revised Date:  2008-09-25    
Medline Journal Info:
Nlm Unique ID:  8700164     Medline TA:  Pediatr Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  63-8     Citation Subset:  IM    
Affiliation:
Baskent University Faculty of Medicine, Department of Pediatric Hematology, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Amphotericin B / therapeutic use*
Antifungal Agents / therapeutic use*
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Aspergillosis / complications,  drug therapy*
Echinocandins
Esophageal Diseases / complications,  drug therapy*
Humans
Leukemia, Megakaryoblastic, Acute / complications*,  drug therapy
Male
Peptides, Cyclic / therapeutic use*
Chemical
Reg. No./Substance:
0/Antifungal Agents; 0/Echinocandins; 0/Peptides, Cyclic; 0/caspofungin; 0/liposomal amphotericin B; 1397-89-3/Amphotericin B

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