Document Detail

Invasive candidiasis in preterm neonates in China: a retrospective study from 11 NICUs during 2009-2011.
MedLine Citation:
PMID:  24153006     Owner:  NLM     Status:  Publisher    
BACKGROUND:: Candida species is an important cause of nosocomial infection in neonatal intensive care units (NICUs). However, most reports in China have been limited to single institutions. The aim of this study is to investigate the epidemiology of invasive candidiasis in multiple NICUs across China.
METHODS:: We retrospectively collected demographic data, clinical characteristics, microbiological results and outcome of preterm infants with invasive candidiasis discharged from 11 academic tertiary NICUs during January 2009 - December 2011.
RESULTS:: There were 30,045 preterm infants discharged from 11 NICUs during the study period. We detected 223 infants with invasive candidiasis, resulting in an incidence of 0.74 cases per 100 preterm discharges from NICUs. In very low birth weight infants, the incidence was 3.42 cases per 100 VLBW discharges. Mean gestational age of infected infants was 31.4 weeks and median birth weight 1410 gram. Among the cohort of infants with invasive candidiasis, 214 (96.0%) infants had positive blood culture for fungus, 5 infants had positive urine culture, 3 from cerebrospinal fluid (CSF) and 1 from articular effusion in the shoulder joint. Among the cohort of infants with candidemia, 48 (22.4%) infants had fungal meningitis. Candida albicans accounted for 57.4% of total positive cultures. Overall mortality attributable to invasive candidiasis was 19.3%.
CONCLUSIONS:: Invasive candidiasis is a common problem among preterm neonates in China, especially among VLBW infants and it is associated with a high mortality. The preponderance of infections was due to Candida albicans.
Hongping Xia; Hui Wu; Shiwen Xia; Xiaoyu Zhu; Chao Chen; Gang Qiu; Wei Zhou; Yingying Shi; Liya Ma; Jianhua Sun; Xiaoyu Zhou; Jianxing Zhu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-22
Journal Detail:
Title:  The Pediatric infectious disease journal     Volume:  -     ISSN:  1532-0987     ISO Abbreviation:  Pediatr. Infect. Dis. J.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701858     Medline TA:  Pediatr Infect Dis J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aXin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China bFirst Hospital of Jilin University, Changchun, China cHubei Maternity and Child Health Hospital, Hubei, China dShenzhen Maternity Hospital, Guangdong, China eChildren's Hospital of Fudan University, Shanghai, China fShanghai Children's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China gGuangzhou Women and Children's Medical Center, Guangdong, China hInternational Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China iShenzhen Bao'an Maternity Hospital, Guangdong, China jShanghai children's medical center, Shanghai Jiao Tong University School of Medicine, Shanghai, China kNanjing Children's Hospital, Nanjing Medical University, Nanjing, China.
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