Document Detail

Invasive activity and chemotactic response to growth factors by Kaposi's sarcoma cells.
MedLine Citation:
PMID:  3379106     Owner:  NLM     Status:  MEDLINE    
Kaposi's sarcoma (KS) is a relatively low grade neoplasm, classically occurring in the skin of elderly men. A more virulent and invasive form of Kaposi's sarcoma has been described in patients with acquired immune deficiency syndrome (AIDS). The origin and identification of the tumor cells in these lesions is controversial. Here we have studied the behavior of cells derived from KS lesions in an in vitro assay which measures the ability of cells to invade through a reconstituted basement membrane. In agreement with previous work, KS cells obtained under selective culture conditions were invasive showing activity comparable to that of malignant tumor cells. Normal fibroblasts, smooth muscle cells, and endothelial cells did not demonstrate invasive behavior under the same experimental conditions. To characterize further the nature of the KS cells we tested the chemotactic response of cells from the most invasive line to a variety of growth factors and compared their response to those of fibroblasts, smooth muscle, and endothelial cells. These studies suggest that normal cells respond to a unique repertoire of chemotactic factors. The chemotactic response of the KS cells most closely resembled that of smooth muscle cells and was quite distinct from endothelial cells. These results indicate that the KS-derived cultures contain invasive cells with a smooth muscle cell-like phenotype.
A Albini; C D Mitchell; E W Thompson; R Seeman; G R Martin; A E Wittek; G V Quinnan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cellular biochemistry     Volume:  36     ISSN:  0730-2312     ISO Abbreviation:  J. Cell. Biochem.     Publication Date:  1988 Apr 
Date Detail:
Created Date:  1988-07-25     Completed Date:  1988-07-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8205768     Medline TA:  J Cell Biochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  369-76     Citation Subset:  IM; X    
Laboratory for Developmental Biology and Anomalies, National Institute of Dental Research, Bethesda, MD 20892.
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MeSH Terms
Fibroblasts / pathology
Growth Substances / pharmacology*
Neoplasm Invasiveness
Sarcoma, Kaposi / immunology,  pathology*
Tumor Cells, Cultured / immunology,  pathology
Reg. No./Substance:
0/Growth Substances

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