Document Detail


Invasive Scopulariopsis brevicaulis infection in an immunocompromised patient and review of prior cases caused by Scopulariopsis and Microascus species.
MedLine Citation:
PMID:  22524638     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Scopulariopsis species and their Microascus teleomorphs are cosmopolitan fungi that are uncommonly associated with invasive disease. This report describes a case of fatal disseminated Scopulariopsis brevicaulis disease in a patient with diffuse large B cell lymphoma who underwent high-dose chemotherapy followed by a matched unrelated donor stem cell transplant. This case is compared with 32 prior cases of proven invasive Scopulariopsis (Microascus) infections reported in the literature. A focus of this report is the diagnostic methods utilized which included histopathology and culture with both micromorphologic and genotypic procedures employed to confirm the species identification.
Authors:
Peter C Iwen; Stephanie D Schutte; Diana F Florescu; Rhonda K Noel-Hurst; Lynne Sigler
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-04-23
Journal Detail:
Title:  Medical mycology     Volume:  50     ISSN:  1460-2709     ISO Abbreviation:  Med. Mycol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-17     Completed Date:  2012-11-08     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  9815835     Medline TA:  Med Mycol     Country:  England    
Other Details:
Languages:  eng     Pagination:  561-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Base Sequence
Delayed Diagnosis
Fatal Outcome
Hematopoietic Stem Cell Transplantation
Humans
Immunocompromised Host*
Lymphoma, Large B-Cell, Diffuse / drug therapy,  pathology
Male
Microbiological Techniques / methods
Mycoses / diagnosis,  microbiology,  pathology*
Opportunistic Infections / diagnosis,  pathology
Scopulariopsis / classification,  genetics,  isolation & purification*,  pathogenicity
Sequence Homology
Silver Staining / methods
Transplantation, Homologous

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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