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Invasive Pneumococcal Disease in Infants Younger Than 60 Days.
MedLine Citation:
PMID:  22315484     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Objective. To review the epidemiology and clinical course of invasive pneumococcal diseases of infants younger than 60 days. Study design. All Streptococcus pneumoniae strains isolated from blood and cerebrospinal fluid cultures of infants below the age of 60 days during the years 1999-2009 were included in this study. Demographic, clinical, and laboratory data were collected from medical records. Results. In all, 24 cases of pneumococcal invasive infections were identified. The primary diagnoses were bacteremia without a focus (n = 13), meningitis (n = 6), bacteremia with otitis media (n = 3), and joint infection with bacteremia (n = 2). Only one of the serotypes found is included in the heptavalent pneumococcal conjugated vaccine (PCV7). Conclusions. Streptococcus pneumoniae should be considered and treated empirically in infants with suspected invasive bacterial disease during the first 60 days of life. Routine vaccination with PCV7 in not expected to substantially reduce the incidence of invasive pneumococcal disease in Israeli infants of this age as a result of herd immunity.
Authors:
Limor Ashkenazi; Maskit Bar-Meir; Yechiel Schlesinger; Orli Megged
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-2-7
Journal Detail:
Title:  Clinical pediatrics     Volume:  -     ISSN:  1938-2707     ISO Abbreviation:  -     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-2-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of pediatrics and Infectious Diseases Unit, Shaare Zedek Medical Center affiliated with Hadassah-Hebrew University Medical School, Jerusalem, Israel.
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