Document Detail

Invasive breast carcinoma arising in microglandular adenosis: a case report and review of the literature.
MedLine Citation:
PMID:  19824997     Owner:  NLM     Status:  MEDLINE    
Microglandular adenosis of the breast is an extremely rare, benign lesion. Carcinoma arising in microglandular adenosis has been reported in up to 27% of patients with microglandular adenosis. We reported a case of invasive carcinoma arising in microglandular adenosis. A lumpectomy was performed on a 42-year-old female because of a mass in the right breast. Grossly, the lesion was ill-defined with thickened areas. Histologically, this case was consistent with carcinoma arising in microglandular adenosis and showed clear transition from microglandular adenosis through atypical microglandular adenosis to in situ and invasive carcinoma. All the epithelial cells were positive for cytokeratin7, S-100 protein, but negative for estrogen receptor, progesterone receptor, and Her2/Neu. No myoepithelial cells were demonstrable with immunohistochemical staining for smooth muscle actin, muscle-specific antigen or P63. Periodic acid-Schiff staining showed the presence of a basement membrane in microglandular adenosis, atypical microglandular adenosis, in situ carcinoma and the absence in invasive carcinoma. To the best of our knowledge, this is the first reported case of carcinoma arising in microglandular adenosis in China.
Ruohong Shui; Wentao Yang
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Publication Detail:
Type:  Case Reports; Journal Article; Review     Date:  2009-10-12
Journal Detail:
Title:  The breast journal     Volume:  15     ISSN:  1524-4741     ISO Abbreviation:  Breast J     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-12-09     Completed Date:  2010-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9505539     Medline TA:  Breast J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  653-6     Citation Subset:  IM    
Department of Pathology, Cancer Hospital, Fudan University, Shanghai, China.
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MeSH Terms
Breast Neoplasms / chemistry,  pathology*
Carcinoma, Ductal, Breast / chemistry,  pathology*
Fibrocystic Breast Disease / pathology*

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