| Invasion of the leukocytes into the fetal-maternal interface during pregnancy. | |
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MedLine Citation:
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PMID: 20519637 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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No other organ in the body undergoes such an invasion of selective cells (leukocytes) and release of homing molecules, CAMs, proinflammatory cytokines, and mediators or undergoes similar extensive remodeling of tissues over such a short period of time as the pregnant uterus. This is especially interesting, as an infectious process involving microorganisms does not exist in a healthy pregnancy and delivery. Furthermore, after delivery of the baby and placenta, the uterus involutes and returns to its normal monthly cycling, and most of the leukocytes are swept away or leave. In this review, we discuss leukocyte infiltration and recruitment and the potential roles of each subpopulation of leukocytes in relation to pregnancy and the problems of preterm birth, pre-eclampsia, and intrauterine growth restriction. |
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Authors:
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Nardhy Gomez-Lopez; Larry J Guilbert; David M Olson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-06-02 |
Journal Detail:
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Title: Journal of leukocyte biology Volume: 88 ISSN: 1938-3673 ISO Abbreviation: J. Leukoc. Biol. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2010-10-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8405628 Medline TA: J Leukoc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 625-33 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Universityof Alberta, Edmonton, Alberta, Canada. gomezlop@ualberta.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chemokines / immunology Chemotaxis, Leukocyte / immunology* Decidua / immunology* Female Humans Parturition / immunology* Placental Circulation / immunology Pregnancy / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Chemokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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