Document Detail


Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.
MedLine Citation:
PMID:  23334244     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Invariant natural killer T (iNKT) cells exist in a 'poised effector' state, which enables them to rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor, they recognize self and foreign lipid antigens presented by CD1d in a conserved manner, but their activation can catalyse a spectrum of polarized immune responses. In this Review, we discuss recent advances in our understanding of the innate-like mechanisms underlying iNKT cell activation and describe how lipid antigens, the inflammatory milieu and interactions with other immune cell subsets regulate the functions of iNKT cells in health and disease.
Authors:
Patrick J Brennan; Manfred Brigl; Michael B Brenner
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2013-01-21
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  13     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-03-21     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  101-17     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Communication / immunology
Humans
Immunity, Innate*
Leukocytes / immunology,  metabolism
Lymphocyte Activation / immunology*
Natural Killer T-Cells / immunology*,  metabolism
T-Lymphocyte Subsets / immunology,  metabolism
Grant Support
ID/Acronym/Agency:
AI028973/AI/NIAID NIH HHS; AI063428/AI/NIAID NIH HHS; AI077795/AI/NIAID NIH HHS; DK057521/DK/NIDDK NIH HHS; K08 AI077795/AI/NIAID NIH HHS

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