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Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions.
MedLine Citation:
PMID:  23334244     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Invariant natural killer T (iNKT) cells exist in a 'poised effector' state, which enables them to rapidly produce cytokines following activation. Using a nearly monospecific T cell receptor, they recognize self and foreign lipid antigens presented by CD1d in a conserved manner, but their activation can catalyse a spectrum of polarized immune responses. In this Review, we discuss recent advances in our understanding of the innate-like mechanisms underlying iNKT cell activation and describe how lipid antigens, the inflammatory milieu and interactions with other immune cell subsets regulate the functions of iNKT cells in health and disease.
Authors:
Patrick J Brennan; Manfred Brigl; Michael B Brenner
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-21
Journal Detail:
Title:  Nature reviews. Immunology     Volume:  -     ISSN:  1474-1741     ISO Abbreviation:  Nat. Rev. Immunol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101124169     Medline TA:  Nat Rev Immunol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Medicine, Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, One Jimmy Fund Way, Boston, Massachusetts 02115, USA.
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