| Invariant NKT cells modulate the suppressive activity of IL-10-secreting neutrophils differentiated with serum amyloid A. | |
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MedLine Citation:
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PMID: 20890286 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neutrophils are the main effector cells during inflammation, but they can also control excessive inflammatory responses by secreting anti-inflammatory cytokines. However, the mechanisms that modulate their plasticity remain unclear. We now show that systemic serum amyloid A 1 (SAA-1) controls the plasticity of neutrophil differentiation. SAA-1 not only induced anti-inflammatory interleukin 10 (IL-10)-secreting neutrophils but also promoted the interaction of invariant natural killer T cells (iNKT cells) with those neutrophils, a process that limited their suppressive activity by diminishing the production of IL-10 and enhancing the production of IL-12. Because SAA-1-producing melanomas promoted differentiation of IL-10-secreting neutrophils, harnessing iNKT cells could be useful therapeutically by decreasing the frequency of immunosuppressive neutrophils and restoring tumor-specific immune responses. |
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Authors:
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Carmela De Santo; Ramon Arscott; Sarah Booth; Ioannis Karydis; Margaret Jones; Ruth Asher; Mariolina Salio; Mark Middleton; Vincenzo Cerundolo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-03 |
Journal Detail:
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Title: Nature immunology Volume: 11 ISSN: 1529-2916 ISO Abbreviation: Nat. Immunol. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-20 Completed Date: 2010-11-23 Revised Date: 2011-11-28 |
Medline Journal Info:
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Nlm Unique ID: 100941354 Medline TA: Nat Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 1039-46 Citation Subset: IM |
Affiliation:
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Medical Research Council Human Immunology Unit, Nuffield Department of Medicine, Medical Research Council Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / immunology* Cell Line, Tumor Female Humans Interleukin-10 / immunology* Melanoma / immunology* Mice Mice, Inbred C57BL Natural Killer T-Cells / immunology* Neutrophils / cytology, immunology* Serum Amyloid A Protein / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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084923/Z/08/Z//Wellcome Trust; A11331//Cancer Research UK; A6199//Cancer Research UK; C399/A2291//Cancer Research UK; //Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Serum Amyloid A Protein; 130068-27-8/Interleukin-10 |
| Comments/Corrections | |
Comment In:
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Nat Immunol. 2011 Nov;12(11):1017-8; author reply 1018-20
[PMID:
22012430
]
Nat Immunol. 2010 Nov;11(11):981-2 [PMID: 20959800 ] Nat Rev Immunol. 2010 Nov;10(11):752 [PMID: 21080614 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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