Document Detail


Invariant NKT cells from HIV-1 or Mycobacterium tuberculosis-infected patients express an activated phenotype.
MedLine Citation:
PMID:  18304877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The frequency, subsets and activation status of peripheral blood invariant NKT (iNKT) cells were evaluated in pulmonary tuberculosis (TB) patients and in chronically HIV-1-infected subjects. The absolute numbers of iNKT cells were significantly decreased in TB patients and in HIV-1+ individuals who were antiretroviral therapy naive or had detectable viremia despite receiving HAART. iNKT cell subset analysis demonstrated a decreased percentage of CD4(+) iNKT cells in HIV-1+ subjects, and a decreased percentage of double negative iNKT cells in TB patients. Peripheral blood iNKT cells from HIV-1+ and TB patients had significantly increased expression of CD69, CD38, HLA-DR, CD16, CD56, and CD62L. The expression of CD25 was significantly increased only on iNKT cells from TB patients. These findings indicate that peripheral blood iNKT cells in these two chronic infections show an up-regulated expression of activation markers, suggesting their role in the immune response to infection.
Authors:
Carlos J Montoya; Juan C Cataño; Zoraida Ramirez; Maria T Rugeles; S Brian Wilson; Alan L Landay
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-03-04
Journal Detail:
Title:  Clinical immunology (Orlando, Fla.)     Volume:  127     ISSN:  1521-6616     ISO Abbreviation:  Clin. Immunol.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-18     Completed Date:  2008-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883537     Medline TA:  Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Affiliation:
Department of Immunology and Microbiology, Rush University Medical Center, Chicago, IL, USA. cjmonto@une.net.co
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD / metabolism
Antiretroviral Therapy, Highly Active
Cell Count
Female
Flow Cytometry
HIV Infections / drug therapy,  immunology*
HLA-DR Antigens / metabolism
Humans
Killer Cells, Natural / immunology*,  metabolism
Lymphocyte Activation / immunology*
Lymphocyte Subsets / immunology,  metabolism
Male
Middle Aged
Mycobacterium tuberculosis
Phenotype
T-Lymphocytes / immunology*,  metabolism
Tuberculosis, Pulmonary / immunology*
Grant Support
ID/Acronym/Agency:
2R01 AI 45051/AI/NIAID NIH HHS; 5P01 AI055793/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD; 0/HLA-DR Antigens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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