Document Detail

Inulin-type fructans modulate gastrointestinal peptides involved in appetite regulation (glucagon-like peptide-1 and ghrelin) in rats.
MedLine Citation:
PMID:  15469657     Owner:  NLM     Status:  MEDLINE    
The hypothesis tested in the present study is that dietary fructans are able to modulate gastrointestinal peptides involved in the control of food intake, namely glucagon-like peptide (GLP)-1 (7-36) amide and ghrelin. After 3 weeks of treatment with a standard diet (control) or the same diet enriched with 100 g fructans varying in their degrees of polymerization (oligofructose (OFS), Synergy 1 (Syn) or long chain inulin)/kg, male Wistar rats were deprived of food for 8 h before sample collection. Dietary energy intake throughout the experiment was significantly lower (P<0.05) in fructans-fed rats than in control rats, leading to a significant decrease (P<0.01) in epidydimal fat mass at the end of the treatment in OFS- and Syn-treated rats. GLP-1 (7-36) amide concentration in portal vein serum was higher in OFS- and Syn-fed than in control rats. Both GLP-1 (7-36) amide concentration and proglucagon mRNA concentrations were significantly greater (P<0.05) in the proximal colonic mucosa of fructans-fed rats v. controls. Normally active ghrelin concentration in plasma increases during food deprivation and rapidly falls during a meal. In the present study, after 8 h of food deprivation, active ghrelin in the plasma remained significantly lower (P<0.05) in OFS and Syn-fed than in control rats. These results are in accordance with the modifications of dietary intake and fat-mass development in short-chain fructans-treated rats and demonstrate the potential modulation of GLP-1 (7-36) amide and ghrelin by fermentable fibres such as fructans, which are rapidly and extensively fermented in the proximal part of the colon.
Patrice D Cani; Cédric Dewever; Nathalie M Delzenne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of nutrition     Volume:  92     ISSN:  0007-1145     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-07     Completed Date:  2004-11-01     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  521-6     Citation Subset:  IM    
Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Department of Pharmaceutical Sciences, Université Catholique de Louvain, B-1200 Brussels, Belgium.
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MeSH Terms
Appetite Regulation / physiology*
Cecum / metabolism
Colon / metabolism
Eating / physiology
Energy Intake / physiology
Glucagon / metabolism
Glucagon-Like Peptide 1
Glucagon-Like Peptides
Inulin / administration & dosage*,  metabolism
Organ Size / physiology
Peptide Fragments / blood,  physiology*
Peptide Hormones / analysis,  physiology*
Protein Precursors / metabolism
RNA, Messenger / analysis
Rats, Wistar
Weight Gain / physiology
Reg. No./Substance:
0/Ghrelin; 0/Peptide Fragments; 0/Peptide Hormones; 0/Protein Precursors; 0/RNA, Messenger; 119637-73-9/glucagon-like peptide 1 (7-36)amide; 55963-74-1/Proglucagon; 62340-29-8/Glucagon-Like Peptides; 89750-14-1/Glucagon-Like Peptide 1; 9005-80-5/Inulin; 9007-92-5/Glucagon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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